This book offers an in-depth exploration of the crucial role of macrophages in the immune system and their complex interaction with inorganic compounds. After setting the general background on macrophages, it dives into the fundamentals of bioinorganics, outlining the key concepts and techniques used in this constantly evolving field.The exploration of bioinorganic interactions in macrophages sheds light on the mechanisms of metal ion uptake, their role in cellular processes and the impact of inorganic nanoparticles. Particular attention is paid to the function of nitric oxide (NO) in macrophage activity, with its therapeutic implications and challenges.Focusing on innovative medical applications, the book explores strategies for targeting macrophages in the treatment of inflammatory diseases and novel approaches for modulating their activity in cell therapy. In conclusion, it highlights the growing importance of bioinorganics in understanding macrophages and offers promising prospects for future research.