This work is an attempt to outline the status of Malaria in Wau Town as one of the areas that have prevalence of malaria in South Sudan. The author collected both primary and retrospective data in community setup and in the health facilities, which eventually were analyzed and came up with this work. The work was submitted to the college in partial fulfillment of master of science in microbiology in the college of Natural Science - Addis Ababa University 2017.