To present a coherent and meaningful survey of scientific research endeavour in an area that has expanded as fast as physiology and biochemistry of reproduction in the male is no mean task these days. No less prodigious than the growth of knowledge of male reproductive function has been the rate at which the outpouring of publications on this subject has continued since the appearance of 'The Biochemistry of Semen and of the Male Reproductive Tract' in 1964. Since cyclopaedic treatment of this vast literature did not appeal to us, we have made no attempt either to rehash the material contained…mehr
To present a coherent and meaningful survey of scientific research endeavour in an area that has expanded as fast as physiology and biochemistry of reproduction in the male is no mean task these days. No less prodigious than the growth of knowledge of male reproductive function has been the rate at which the outpouring of publications on this subject has continued since the appearance of 'The Biochemistry of Semen and of the Male Reproductive Tract' in 1964. Since cyclopaedic treatment of this vast literature did not appeal to us, we have made no attempt either to rehash the material contained in that book or to enlarge the bibliography beyond the nearly 3500 references included in the present treatise. At the same time, whilst writing, we felt strongly that to advance, it is necessary to understand the past, and for this reason we have not hesitated to refer (especially in the introductory chapter) to a number of those fundamental early discoveries in which today's knowledge is deeply and firmly rooted.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
I Male Reproductive Function and the Composition of Semen: General Considerations.- 1. Functional Dualism of the Testis.- 2. Male Reproductive Tract: Main Characteristics.- 3. Coordination of Male Reproductive Function by Extragonadal Hormones and Environmental Factors.- 4. Cardinal Properties of Spermatozoa.- 5. General Features of the Seminal Plasma.- 6. Spermatophores and Spermatophoric Reaction.- II Methodological Guidelines in the Study of Male Reproductive Organs.- 1. Andrological Examination of the Testis and Androgen Assays.- 2. Cannulation, Micropuncture, Perfusion and Transplantation Techniques.- 3. Isolation of Seminiferous Tubules and Disaggregation of Germinal Cells and Sertoli Cells.- 4. Cell and Organ Cultures.- III Collection, Examination, Quality Rating and Storage of Ejaculated Semen.- 1. Collection of Whole and Split Ejaculates, and Separation of Spermatozoa from Seminal Plasma.- 2. Separation of Motile from Immotile, and Male-determining from Female-determining Spermatozoa.- 3. Examination of Spermatozoa and Isolated Structural Components.- 4. Quality Rating of Semen in Andrological Practice.- 5. Storage of Semen for Artificial Insemination.- IV Testis and Testicular Semen.- 1. Spermatogenesis.- 2. Steroidogenesis.- 3. Testicular Semen.- V Epididymis and Epididymal Semen.- 1. Functional Characteristics of the Epididymis.- 2. Epididymal Spermatozoa.- 3. Epididymal Plasma.- 4. Metabolism of the Epididymis and Epididymal Semen.- VI Vas Deferens and Vasectomy.- 1. Structural and Functional Features of the Deferent Duct.- 2. Vasectomy and Vasoligation.- VII Secretory Function of the Prostate, Seminal Vesicle, Cowper's Gland and Other Accessory Organs of Reproduction.- 1. Secretory Mechanisms.- 2. Androgen-dependent Maintenance of Growth, Metabolism andSecretory Activity in Male Accessory Organs.- 3. Overall Pattern and Mechanism of Hormonal Regulation.- 4. Comparative Andrological Aspects.- VIII Biochemistry of Spermatozoa: Chemical and Functional Correlations in Ejaculated Semen, Andrological Aspect.- 1. Chemical and Metabolic Characteristics of Ejaculated Spermatozoa; Comparative Viewpoint.- 2. Sperm Plasma Membrane; Permeability and Binding Properties.- 3. Acrosome and Lysosomal Enzymes.- 4. Sperm Nucleus: Nucleic Acid and Nuclear Proteins.- 5. Mitochondria and their Role in Sperm Metabolism and Energetics.- 6. Flagellum and the Mechanochemical Basis of Motility.- 7. Cyclic Nucleotides and Other Promoters of Sperm Activity.- IX Biochemistry of Seminal Plasma and Male Accessory Fluids; Application to Andrological Problems.- 1. Chemical Analysis of Seminal Plasma and Interpretation of Results.- 2. Ions, Free and Bound.- 3. Proteins and Enzymes.- 4. Peptides, Amino Acids and Nitrogenous Bases.- 5. Fructose, Other Sugars, Polyols and Bound Carbohydrate.- 6. Lipids, Cholesterol and Steroid Hormones.- 7. Prostaglandins and Other Organic acids.- 8. Biochemical Basis of Interactions between the Male Accessory Secretions, and between the Seminal Plasma and Spermatozoa.- 9. Examination of Whole Seminal Plasma and Split Ejaculatory Fractions as a Diagnostic Aid in Reproductive Disorders.- X Effects of Pharmacological Agents: Andrological Aspects. Drug Abuse, Therapeutic Agents, Male Contraceptives, Occupational Hazards.- 1. Psycbomimetic and Psycbotberapeutic Drugs.- 2. Ampbetamines, Cocaine and Alcobol.- 3. Passage of Drugs and Otber Substances into Semen.- 4. Control of tbe Ejaculatory Process by Sympatbomimetic, Parasympatbomimetic and Autonomic-blocking Agents.- 5. Chemosterilants as Potential Male Contraceptives.- 6. Dietary Factors, Food Additives and Antimetabolites.- 7. Cadmium-induced Damage in tbe Testis and Countereffect of Zinc and Selenium.- 8. Steroids and Otber Suppressors of Spermatogenesis Acting via tbe Pituitary Gland.- 9. Antiandrogens.- 10. Antimitotic and Antimeiotic Cbemicals; Colcbicine, Alkylating Agents, Heterocyclic Compounds.- 11. Chemotherapeutic Drugs, Industrial Chemicals and Pesticides.- 12. ?-Chlorohydrin.- 13. Biochemical Basis of Spermiostatic and Spermicidal Activity.- References.
I Male Reproductive Function and the Composition of Semen: General Considerations.- 1. Functional Dualism of the Testis.- 2. Male Reproductive Tract: Main Characteristics.- 3. Coordination of Male Reproductive Function by Extragonadal Hormones and Environmental Factors.- 4. Cardinal Properties of Spermatozoa.- 5. General Features of the Seminal Plasma.- 6. Spermatophores and Spermatophoric Reaction.- II Methodological Guidelines in the Study of Male Reproductive Organs.- 1. Andrological Examination of the Testis and Androgen Assays.- 2. Cannulation, Micropuncture, Perfusion and Transplantation Techniques.- 3. Isolation of Seminiferous Tubules and Disaggregation of Germinal Cells and Sertoli Cells.- 4. Cell and Organ Cultures.- III Collection, Examination, Quality Rating and Storage of Ejaculated Semen.- 1. Collection of Whole and Split Ejaculates, and Separation of Spermatozoa from Seminal Plasma.- 2. Separation of Motile from Immotile, and Male-determining from Female-determining Spermatozoa.- 3. Examination of Spermatozoa and Isolated Structural Components.- 4. Quality Rating of Semen in Andrological Practice.- 5. Storage of Semen for Artificial Insemination.- IV Testis and Testicular Semen.- 1. Spermatogenesis.- 2. Steroidogenesis.- 3. Testicular Semen.- V Epididymis and Epididymal Semen.- 1. Functional Characteristics of the Epididymis.- 2. Epididymal Spermatozoa.- 3. Epididymal Plasma.- 4. Metabolism of the Epididymis and Epididymal Semen.- VI Vas Deferens and Vasectomy.- 1. Structural and Functional Features of the Deferent Duct.- 2. Vasectomy and Vasoligation.- VII Secretory Function of the Prostate, Seminal Vesicle, Cowper's Gland and Other Accessory Organs of Reproduction.- 1. Secretory Mechanisms.- 2. Androgen-dependent Maintenance of Growth, Metabolism andSecretory Activity in Male Accessory Organs.- 3. Overall Pattern and Mechanism of Hormonal Regulation.- 4. Comparative Andrological Aspects.- VIII Biochemistry of Spermatozoa: Chemical and Functional Correlations in Ejaculated Semen, Andrological Aspect.- 1. Chemical and Metabolic Characteristics of Ejaculated Spermatozoa; Comparative Viewpoint.- 2. Sperm Plasma Membrane; Permeability and Binding Properties.- 3. Acrosome and Lysosomal Enzymes.- 4. Sperm Nucleus: Nucleic Acid and Nuclear Proteins.- 5. Mitochondria and their Role in Sperm Metabolism and Energetics.- 6. Flagellum and the Mechanochemical Basis of Motility.- 7. Cyclic Nucleotides and Other Promoters of Sperm Activity.- IX Biochemistry of Seminal Plasma and Male Accessory Fluids; Application to Andrological Problems.- 1. Chemical Analysis of Seminal Plasma and Interpretation of Results.- 2. Ions, Free and Bound.- 3. Proteins and Enzymes.- 4. Peptides, Amino Acids and Nitrogenous Bases.- 5. Fructose, Other Sugars, Polyols and Bound Carbohydrate.- 6. Lipids, Cholesterol and Steroid Hormones.- 7. Prostaglandins and Other Organic acids.- 8. Biochemical Basis of Interactions between the Male Accessory Secretions, and between the Seminal Plasma and Spermatozoa.- 9. Examination of Whole Seminal Plasma and Split Ejaculatory Fractions as a Diagnostic Aid in Reproductive Disorders.- X Effects of Pharmacological Agents: Andrological Aspects. Drug Abuse, Therapeutic Agents, Male Contraceptives, Occupational Hazards.- 1. Psycbomimetic and Psycbotberapeutic Drugs.- 2. Ampbetamines, Cocaine and Alcobol.- 3. Passage of Drugs and Otber Substances into Semen.- 4. Control of tbe Ejaculatory Process by Sympatbomimetic, Parasympatbomimetic and Autonomic-blocking Agents.- 5. Chemosterilants as Potential Male Contraceptives.- 6. Dietary Factors, Food Additives and Antimetabolites.- 7. Cadmium-induced Damage in tbe Testis and Countereffect of Zinc and Selenium.- 8. Steroids and Otber Suppressors of Spermatogenesis Acting via tbe Pituitary Gland.- 9. Antiandrogens.- 10. Antimitotic and Antimeiotic Cbemicals; Colcbicine, Alkylating Agents, Heterocyclic Compounds.- 11. Chemotherapeutic Drugs, Industrial Chemicals and Pesticides.- 12. ?-Chlorohydrin.- 13. Biochemical Basis of Spermiostatic and Spermicidal Activity.- References.
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