Malignant Brain Tumours

Herausgegeben:Thomas, David G.T.; Graham, David I.

• Broschiertes Buch

Produktbeschreibung

Malignant brain tumours remain a not uncommon cause of disability and premature death, particularly in children and middle-aged adults. This is only too weIl known by those con cerned with the dinical management of such patients. Thus, not onlyare malignant cerebral gliomas very aggressive tumours, usually associated with a rapidly fatal outcome, but also it has been recognised more recently that low grade gliomas often have a poor prognosis. Furthermore, the increased application of non-invasive neuroradiological imaging to patients with other types of tumour has disdosed an even larger number of metastatic brain tumours than has been recognised previously. In the last decade, the spectrum of malignant brain tumours has been further widened by the ons et of tumours related to acquired immunodeficiency syndrome (AIDS). Nevertheless, all is not gloom, and within the community of life-science profes sionals in the neuro-oncological specialities, both scientific and dinicaI, there is some optimism that matters, albeit slowly, will change for the better. This hope is based largely on the realis ation that large amounts of pertinent information exist about the biology of these tumours at molecular and cellular levels. It is also based on the ability to image them by eT and MR methods, often at an early stage in the disease, as well as on the capacity to achieve accurate histopathological correlation with the diagnostic imaging. Thus, the necessary prerequisites for the optimum treatment of these diseases by surgery, by radiation, and by drug treatment exist.

Produktdetails

• Verlag: Springer / Springer London / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4471-1879-4
• Softcover reprint of the original 1st ed. 1995
• Seitenzahl: 420
• Erscheinungstermin: 23. November 2011
• Englisch
• Abmessung: 235mm x 155mm x 23mm
• Gewicht: 634g
• ISBN-13: 9781447118794
• ISBN-10: 1447118790
• Artikelnr.: 39509097

Autorenporträt

Malignant Brain Tumours is an excellent compendium of current thought and practice for clinicians, surgeons, and scientists. Additionally, it is an invaluable reference for graduate and post-graduate students. This book could also be used as a very comprehensive teaching text.

Inhaltsangabe

1 Cellular and Molecular Approaches to the Study of Gliomas and Glial Development.- Glial cell development in the rat optic nerve.- Control of self-renewal in the O-2A lineage.- Glial and neuronal development in the retina and cortex.- Ramifications of current development studies for neuropathology.- Potential for positive feedback loops as contributors to growth of gliomas.- Conclusion.- References.- 2 Molecular Genetics of Brain Tumours.- Genetic techniques in studies of brain tumours.- Molecular basis of tumorigenesis.- Molecular genetics of benign brain tumours.- Cytogenetic and molecular genetic studies of malignant brain tumours: gliomas.- Oncogenes and gliomas.- Molecular genetics of neuroblastomas.- Conclusion.- References.- 3 Current Concepts of the Histopathological Classification of Tumours of the Central Nervous System.- Tumours of neuroepithelial tissue.- References.- Colour plate section appears between pages 42 and 43.- 4 General Introduction to the Clinical Features of Malignant Brain Tumours.- Epidemiology.- Clinical presentation of primary malignant brain tumours.- Specific clinical syndromes.- Glioblastoma.- References.- 5 Complications of Primary Malignant Brain Tumours.- Complications of the tumour itself.- Complications of treatment.- References.- 6 Low-grade Gliomas.- Low-grade cerebral astrocytoma.- Neurosurgical management.- Evaluation of surgical results.- Future Considerations.- Acknowledgements.- References.- 7 Management of Brain Tumours in Childhood.- Introduction: the sites; the cells; the patients.- Primitive neuroectodermal tumour (PNET).- Brain stem glioma.- Craniopharyngioma.- Ependymoma.- Pineal region tumours.- Conclusion.- References.- 8 Central Nervous System Neoplasms in Acquired Immunodeficiency Syndrome.- Primary CNS lymphoma.-Systemic non-Hodgkin's lymphoma.- Kaposi's sarcoma.- Pathogenesis of neoplasms in immune deficiency.- References.- 9 Metastatic Brain Tumours.- General aspects.- Signs and symptoms.- Investigations.- Treatment.- Outcome of treatment.- References.- 10 Diagnostic Imaging of Brain Tumours.- Detection of an abnormality.- Localization and assessment of extent of abnormality.- Characterization of a lesion.- Imaging characteristics of intrinsic tumours.- Facilitation of treatment and further surgical planning.- Monitoring of therapy and outcome of treatment.- References.- 11 Surgery for Primary Malignant Brain Tumours.- Historical introduction.- Principles of surgery.- Principles of perioperative care.- Surgical methods.- Additional surgical methods.- Surgical treatment of gliomas within a specific site.- Recent advances in surgical methods.- Results of surgery.- The case for reoperation for gliomas.- Conclusion.- References.- 12 Radiotherapy for Malignant Brain Tumours.- Biological basis of radiotherapy.- Radiation tolerance of the central nervous system.- Radiotherapy technique.- New radiotherapy techniques.- Radiotherapy in specific tumours.- Radiotherapy in other tumours: optic nerve glioma; meningioma; craniopharyngioma.- Conclusion.- References.- 13 Chemotherapy of Malignant Brain Tumour.- Summary.- Special features of chemotherapy of malignant brain tumours.- Specific treatment.- Clinical classification of malignant CNS neoplasia.- Conclusion.- Appendix I: Some abbreviations and acronyms.- References.- 14 Immunotherapy of Brain Tumours.- Brain tumour immunology: surface antigens on brain tumour; humoral immune response; cell-mediated immune response; modulation of the host immune response by gliomas.- Immunotherapy.- References.

Rezensionen

"...an example of an excellent co-operation between neurosurgery and neuropathology...an excellent compendium of current thought and practice of brain tumours...The book may serve as a reference both for study, practice, research and teaching. It can be fully recommended" - Journal of Brain Research