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Diseases caused by Fusarium solani are very common and occur world wide. Control of pathogenic fungi has become an obligatory requirement. Chemical control is the most commonly used but the biological control being the most popular way of controlling the pathogenic fungi. Natural plants products are biodegradable, exhibit structural diversity and complexity and used traditionally to treat a number of infectious diseases including those caused by bacteria, fungi, protozoa and viruses. On the basis of efficacy of plant extracts, present study has been designed to find out the effective plant product for the management of F. solani by using Parthenium hysterophorus and molecular characterization of Fusarium solani.