The potential always exists for development of a medical emergency in a medically compromised patient. Enough emphasis cannot be given to the importance of a detailed history taking. All dentists and dental office staff must be prepared to recognize and treat adverse responses using appropriate current guidelines. Although there is a huge range of systemic illnesses, this chapter focused on only selected conditions that need utmost care. Endodontic therapy rather than extraction, maybe the treatment of choice for medically compromised patients due to their health condition as well as psychological status. Today, endodontists are very well informed regarding systemic diseases and can deliver a high standard of endodontic treatment, while at the same time minimizing the potential problem related to general health of the patient.
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