Mesquite {Prosopis juliflora (Swartz) DC}, a fabaceae, native to South America was first introduced into Sudan in 1917. Since then the plant, reintroduced several times from different sources, was deliberately distributed into several ecological zones to curb desert encroachment, provide fuel wood and fodder for animals. However, the plant has spread, become a weed of national importance and a threat to agriculture, pastoralism and biodiversity.