The premise of this work is the realization that cancer cannot be treated by single specialty. The surgeon, medical oncologist and radiation oncologist should not work in the secluded sphere of his/her own domain. Instead, successful management of the cancer patient should incorporate the best that each of these specialties has to offer. Added to the list of the necessary healthcare professionals are genetic counselors, pain specialists and nutrition experts. This is a retrospective cohort study conducted in the National Cancer Institute - Cairo University to review our own experience in management of the ovarian sex cord stromal tumors. Ovarian sex cord-stromal tumors are a heterogeneous group of benign or malignant neoplasms that develop from the dividing cells that normally produce cells that support and surround the oocytes, including the cells that produce ovarian hormones (the nongerm cell and nonepithelial components of the gonads). Out of 114 patients, 25 (21.9%) were benign and 25 (21.9%) were borderline malignant; 55 (48.2%) were malignant and 9 (7.89%) of them had unpredicted biologic behavior. The median age of the study population was 49.7 years (range: 14-83 years).