Potato Tuber Moth, Phthorimea operculella is one of potato insect pest infesting in field and store to cause of yield reduction. For the past many years controlled by using insecticides has developed resistance to a variety of insecticides rapidly, hence effective controlling foliage attack with current insecticides have not prevented occurrence of high level of tuber infestation. This book therefore, insect pathogens and selected cultural practice could provide a break from continuous insecticide selective pressure, effective control, safe to handle, safe methods and free of any insecticide residual effect.