HIV-related mortality in Mali was estimated at 33 per 100,000 in 2012, and the prevalence of Tuberculosis/HIV co-infection was 14% in the same year. Tuberculosis is the leading cause of HIV-related mortality. Objective: the aim of the present study is to evaluate the management of tuberculosis/HIV co-infection at the Kénédougou Solidarité referral center in the Sikasso region of Mali between January 2008 and December 2013. Methods: we conducted a retrospective study of patients aged 15 and over, collecting data from patient records, registration registers, pharmacy registers and a patient-tracking software program used at the facility. Results: The prevalence of patients co-infected with HIV and tuberculosis was 5.24%. The rate of completion of complementary check-ups for inclusion was 72.82%, compared with 64.08% for follow-up check-ups for HIV-TB patients. The main difficulties were access to complementary check-ups and access to anti-tuberculosis drugs. ARVs are dispensed at the facility, as are drugs for certain OIs.