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The objective of this Manual on common bacterial diseases of large animals (MCBDLA) is to provide information on epidemiology, clinical symptoms, diagnosis, treatment and prevention and control of large animals bacterial diseases. In writing this manual, we have made our utmost effort to review available literature both locally and internationally and compile our knowledge, which we have acquired during our long experience in clinical practice, diagnostic and research laboratories, teaching and veterinary medicine. The MCBDLA is organized as a collection so that clinicians or those involved in the veterinary profession could be able to refer it within a short time possible. Despite the fact that many diseases affect different species of animals, an account of each disease has been described separately. However, a full account of the disease in each animal species is given only when there is a significant difference in the epidemiology or clinical symptoms. In as much as possible,the most important descriptions of the epidemiology, clinical symptoms, diagnosis, and treatment are included. Much emphasis is given to the treatment part to select the most effective and economical drugs, which is acceptable by the practicing veterinarians and the farmers. Since prevention is, in most part, more economical than the clinical handling of sick animals, appropriate preventive and control measures are described in each section.