Marine Biomedicine

From Beach to Bedside
Herausgeber: Baker, Bill J

• Gebundenes Buch

Produktbeschreibung

This book assesses current efforts in marine biomedicine and evaluates the implications of recent advances on the future of the field. The book covers four sections. The first one addresses the technology that has recently been brought to bear on the study of marine natural products, including omic and bioinformatic techniques. The second focuses on lead discovery and reviews various products and their activities. Examples of clinically successful marine products and discussions of approaches to the clinic are presented in the third section while the last section discusses prospects for the future of marine biodiscovery.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 594
• Erscheinungstermin: 6. November 2015
• Englisch
• Abmessung: 257mm x 180mm x 33mm
• Gewicht: 1451g
• ISBN-13: 9781466582125
• ISBN-10: 146658212X
• Artikelnr.: 43023445

Autorenporträt

Edited by Bill J. Baker is a professor of chemistry and director of University of South Florida's Center for Drug Discovery and Innovation in Tampa. He earned a BS in chemistry from Cal Poly in San Luis Obispo, California, and his PhD from the University of Hawaii. Dr. Baker conducted postdoctoral research with Ron Parry at Rice University and Carl Djerassi at Stanford University. He is currently visiting Beaufort professor of marine biodiscovery at the National University of Ireland Galway. His research interests in marine natural product chemistry have taken him all over the globe, including 12 field seasons of research in Antarctica.

Inhaltsangabe

MARINE BIOTECHNOLOGY: INFORMING THE SEARCH. Accessing Chemical Diversity
through Metagenomics. Chemical Characterization of Marine Organisms Using a
Metabolomic Approach. Biosynthetic Approaches to Marine Drug Discovery and
Development. Dereplication of Natural Products Using Databases. MARINE
BIODISCOVERY: LEAD DISCOVERY. Logistic Considerations to Deliver Natural
Product Libraries for High-Throughput Screening. Screening Marine Microbial
Libraries. Screening Strategies for Drug Discovery and Target
Identification. Anti-Infective Agents from Marine Sources. Screening for
Antiparasitic Marine Natural Products. Central Nervous System Modulators
from the Oceans. Marine Organisms in Cancer Chemoprevention. Off the Beaten
Path: Natural Products from Extreme Environments. Bioprospecting Fungi and
the Labyrinthulomycetes at the Ocean-Land Interface. Medicinal Chemistry
and Lead Optimization of Marine Natural Products. MARINE PRODUCTS IN
BIOMEDICINE. The Travails of Clinical Trials with Marine-Sourced Compounds.
Conopeptides, Marine Natural Products from Venoms: Biomedical Applications
and Future Research Applications. Development and Commercialization of a
Fully Synthetic Marine Natural Product Analogue, Halaven (Eribulin
Mesylate). Marine Natural Products in Pharma: How Industry Missed the Boat.
In Vitro Model for Defining Neurotoxicity of Anticancer Agents. PROSPECTS
FOR THE FUTURE OF MARINE BIODISCOVERY.
Comments on the Past and Future of Marine Natural Product Drug Discovery.