Christoph A Schalley, Andreas Springer

Mass Spectrometry and Gas-Phase Chemistry of Non-Covalent Complexes

• Gebundenes Buch

Produktbeschreibung

The book bridges the gap between mass spectrometry and supramolecular chemistry, which until now were commonly deemed incompatible. The coverage resolves points of error and misinterpretation that have plagued the use of mass spectrometry in supramolecular chemistry. It provides a brief introduction to mass spectrometry and supramolecular chemistry in order to orient the audience. The text also offers supramolecular chemists a detailed introduction to mass spectrometric methodology, and identifies chemical questions that mass spectrometry can answer, citing illustrative examples and discussing them in detail.

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Produktdetails

• Verlag: John Wiley & Sons / Wiley
• Seitenzahl: 592
• Erscheinungstermin: 1. September 2009
• Englisch
• Abmessung: 236mm x 157mm x 30mm
• Gewicht: 898g
• ISBN-13: 9780470131152
• ISBN-10: 0470131152
• Artikelnr.: 26607255

Autorenporträt

Christoph A. Schalley, PhD, is a professor of organic chemistry at Freie Universität Berlin. He received his PhD with Helmut Schwarz at the Technische Universität Berlin followed by a postdoctorate with Julius Rebek, Jr., at The Scripps Research Institute in California. He has authored more than 120 publications and edited seven books. He was awarded the Dozentenstipendium in 2004 of the Fonds der Chemischen Industrie and the Mattauch-Herzog Prize from the German Society of Mass Spectrometry in 2006. Andreas Springer, PhD, received his PhD from the Humboldt-Universität zu Berlin for work with Prof. Michael Linscheid. Currently, he is head of the mass spectrometry core facility of the Department of Chemistry at Freie Universität Berlin, where he is running - besides a collection of up-to-date instruments - one of the oldest, still working EI sector-field instruments worldwide.

Inhaltsangabe

Preface.
List of Tutorials.
PART A: GENERAL ISSUES.
1. INTRODUCTION.
2. SUPRAMOLECULAR CHEMISTRY: SOME BACKGROUND.
2.1. The Nature of Non-Covalent Interactions.
2.2. Classical Building Blocks in Supramolecular Chemistry.
2.3. Key Areas and Key Concepts in Supramolecular Chemistry.
2.4. Biomolecules: Intra- and Intermolecular Non-Covalent Bonds.
References.
3 MASS SPECTROMETRY FOR THE EXAMINATION OF NON-COVALENT COMPLEXES.
3.1. Common Mass Spectrometric Instrumentation for the Examination of
Non-Covalent Bonds.
3.2. How Non-Covalent Bonds Change on the Transition from Solution to the
Gas Phase.
3.3. Ion Energetics Issues.
3.4. Tandem-MS-Experiments.
3.5. Potential Sources of Error or Misinterpretation.
References.
PART B: ARTIFICIAL SUPRAMOLECULAR SYSTEMS. 
4 FUNDAMENTAL STUDIES ON SMALLER NON-COVALENT COMPLEXES.
4.1. Ion Neutral Complexes.
4.2. High-Pressure Mass Spectrometry: Bridging the Gap Between Gas and
Condensed Phase.
References.
5 DETERMINATION OF THE "SECONDARY STRUCTURE" OF SUPRAMOLECULES BY MASS
SPECTROMETRY.
5.1. Mechanically Interlocked Molecules and Their Precursors.
5.2. Guest Encapsulation.
5.3. Gas-Phase Conformations.
5.4. Zwitterions and Salt-Bridges.
References.
6 CHIRAL RECOGNITION.
6.1. Tartrate Clusters.
6.2. Chiral Crown Ether-Ammonium Complexes: The Three-Point Model.
6.3. Cyclodextrin-Amino Acid Recognition.
6.4. Chiral Recognition in Amino Acid Clusters.
6.5. Homochiral Serine Octamers.
6.6. Resonant Two Photon Ionization Studies of Chiral Complexes:
Spectroscopy of Diastereomeric Complexes in the Gas Phase.
References.
7 MONITORING SOLUTION REACTIVITY OF NON-COVALENT COMPLEXES BY MASS
SPECTROMETRY.
7.1. Mass Spectrometric Characterization of Metallo-Supramolecular
Aggregates.
7.2. Simple Ligand Exchanges in Metallo-Supramolecular Squares.
7.3. Titration Experiments with Helicates.
7.4. Helicates Again: Mechanistic Insight into Ligand Exchange Reactions.
7.5. Titration Experiments with Self-Sorting Tetraurea-Calixarenes.
7.6. Self-Sorting Reactions of Pseudorotaxane Assemblies.
7.7. Shorter Time-Scales: A Mixed-Flow Technique Applied to Self-Assembly.
References.
8. GAS-PHASE REACTIVITY OF SUPRAMOLECULES.
8.1. Molecular "Mouse Traps": Covalent Bond Formation Within Non-Covalent
Complexes.
8.2. Fragmentation of Metallo-Supramolecular Helicates, Squares, and Cages.
8.3. Host-Guest Chemistry of Dendrimers in the Gas Phase.
8.4. H/D Exchange Reactions in Gaseous Non-Covalent Complexes.
References.
9 DETERMINATION OF THERMOCHEMICAL DATA.
9.1. Crown Ether Binding Affinities in Solution.
9.2. Ranking of Anion-Cavitand Gas-Phase Binding Energies.
9.3. Crown Ether-Ammonium Ion Complexes in the Gas Phase.
9.4. Crown Ether-Alkali Metal Ion Complexes and the Best-Fit Model.
References.
PART C NON-COVALENT COMPLEXES OF BIOMOLECULES.
10 NON-COVALENT COMPLEXES WITH PETIDES AND PROTEINS.
10.1. Metal-Ion Binding to Peptides and Small Proteins.
10.2. Probing Three-Dimensional Protein Structure and Protein-Protein
Interactions.
10.3. Interactions of Proteins with Small Molecules.
10.4. Sugar-Peptide and Sugar-Protein Complexes.
10.5. Interactions of Proteins with Oligonucleotides, DNA, and RNA.
References.
11. NON-COVALENT COMPLEXES OF NUCLEOTIDES.
11.1. Metal-Ion Binding to DNA Bases and Oligonucleotides.
11.2. Are Watson-Crick Base Pairing and Double Helix Conserved in the Gas
Phase?
11.3. G-Quartets.
11.4. The Folding of G-Rich Strands into Quadruplexes.
11.5. Minor Groove Binders and Intercalators: The Binding to Duplexes.
11.6. Non-Covalent Interactions With G-Quadruplexes.
References.
12. CARBOHYDRATES.
12.1 Carbohydrates: Their Importance and Analysis.
12.2. Stereodifferentiation of Small Carbohydrates.
12.3. Structural Aspects of Oligosaccharides by MS and IMS.
12.4. Carbohydrate Association.
12.5. Summary and Outlook.
References.
13. EPILOGUE.
Index.