Rossi T Rossi

Mass Spectrometry in Drug Discovery

Herausgeber: Rossi, David T; Sinz, Michael W

• Gebundenes Buch

Produktbeschreibung

Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 432
• Erscheinungstermin: 1. November 2001
• Englisch
• Abmessung: 239mm x 162mm x 25mm
• Gewicht: 730g
• ISBN-13: 9780824706074
• ISBN-10: 0824706072
• Artikelnr.: 21191153

Autorenporträt

David T. Rossi

Inhaltsangabe

Introduction: the demand for drug discovery today; the impact of
atmospheric pressure ionisation. Part 1 Instrumentation: a mass
spectrometry primer. Part 2 Experimental strategies: ion chemistry and
fragmentation; the LC/MS experiment; sample preparation and handling for
LC/MS in drug discovery. Part 3 Applications: mass spectrometry in
combinatorial chemistry; drug hydrophobicity and transport; the mass
spectrometer in drug metabolism; mass spectrometry-assisted applications of
stable-labeled compounds in pharmacokinetic and drug metabolism studies;
cassette dosing in drug discovery; applications of microdialysis/mass
spectrometry to drug discovery; future directions for mass spectrometry in
drug discovery.