The Antichrist has arrived, but not to amass an army against God. Isaac is on a Divine mission to destroy mankind, who drifted too far from the shade of the Cross. God anointed a Son, Christ, to try to save the human race, but now has appointed Isaac, Master of Mayhem, to destroy it. He must kill millions to fulfill God's will, and can tolerate zero distractions, which include his wife and sons. His family evidences small murders in Michigan, and flee. He finds them in Ohio being protected by Kalen Gatt, a renowned private detective. Isaac sets fire to a church after locking them inside and continues his harrowing mission. Kale is able to save them from the church fire and vows to stop the mass murderer. Hundreds of thousands are dying in Los Angeles and the same is planned for New York until Isaac learns that his younger son was miraculously cured of Down's syndrome and is a keynote speaker in Las Vegas. Isaac stops by Vegas on his way East to eliminate the nagging distraction. The final confrontation occurs at Caesar's Palace where only one walks away. Kale, who believes REAL men don't cry, prevails but is brought to tears with news from his wife.