This book was written to assist students and researchers needing an introduction to human cardiovascular system's mathematical modelling using simulation tool as MATLAB. A Primary objective of this book is to provide the reader with a guide to mathematical modelling techniques (Lumped Parameter Method) and simulation methods for human cardiovascular System without control System. In this book, Mathematical models for the Heart, Systemic Circulation and Pulmonary Circulation has been explained using Lumped Parameter approach and simulation of the models using Numerical Techniques through MATLAB.