Face is considered as the identity of an individual and any facial deformity can impact the psychological aspect of an individual. Restoration of facial defects is a challenge for both the surgeon and the Prosthodontist. The Prosthodontist is limited by the materials that can mimic the original structures, movable tissue bed, difficulty in retaining large prosthesis and patient acceptance, therefore understanding the material and their properties most important. An attempt has been made to review maxillofacial silicone materials in regard to prosthetic rehabilitation of patients with maxillofacial defects, emphasizing on understanding of anatomical, physiological and psychological well-being of the patients.