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Since 1955, this landmark masterwork has been revered for its authoritative presentation of the entire state of scientific and clinical knowledge about multiple sclerosis. This new edition summarises the state of knowledge on this common neurological disease to mid-2005. No person who aspires to know about multiple sclerosis can do without this book! The state-of-the-art 4th Edition presents the most recent information on the genetics and epidemiology, clinical neurology, pathogenesis, and management of this common neurological disease. Amply illustrated and referenced and beautifully written,…mehr
Since 1955, this landmark masterwork has been revered for its authoritative presentation of the entire state of scientific and clinical knowledge about multiple sclerosis. This new edition summarises the state of knowledge on this common neurological disease to mid-2005. No person who aspires to know about multiple sclerosis can do without this book!
The state-of-the-art 4th Edition presents the most recent information on the genetics and epidemiology, clinical neurology, pathogenesis, and management of this common neurological disease.
Amply illustrated and referenced and beautifully written, McAlpine's Multiple Sclerosis has been described as "A standard reference for multiple sclerosis researchers, embryonic 'MS-ologists' and hard-pressed clinical neurologists alike" (Brain, review of the last edition).
The state-of-the-art 4th Edition presents the most recent information on the genetics and epidemiology, clinical neurology, pathogenesis, and management of this common neurological disease.
Amply illustrated and referenced and beautifully written, McAlpine's Multiple Sclerosis has been described as "A standard reference for multiple sclerosis researchers, embryonic 'MS-ologists' and hard-pressed clinical neurologists alike" (Brain, review of the last edition).
Produktdetails
- Produktdetails
- Verlag: Churchill Livingstone
- 4th ed.
- Seitenzahl: 982
- Erscheinungstermin: September 2006
- Englisch
- Abmessung: 276mm x 219mm x 52mm
- Gewicht: 3180g
- ISBN-13: 9780443072710
- ISBN-10: 044307271X
- Artikelnr.: 20784998
- Verlag: Churchill Livingstone
- 4th ed.
- Seitenzahl: 982
- Erscheinungstermin: September 2006
- Englisch
- Abmessung: 276mm x 219mm x 52mm
- Gewicht: 3180g
- ISBN-13: 9780443072710
- ISBN-10: 044307271X
- Artikelnr.: 20784998
SECTION ONE: THE STORY OF MULTIPLE SCLEROSIS
1. The story of multiple sclerosis
The evolving concept of multiple sclerosis
Naming and classifying the disease: 1868-1983
Clinical descriptions of multiple sclerosis: 1838-1981
Personal accounts of multiple sclerosis: 1824-1991
The social history of multiple sclerosis: 1945-1998
The pathogenesis and clinical anatomy of multiple sclerosis: 1849-1977
The laboratory science of multiple sclerosis: 1912-1981
Discovery of glia and remyelination: 1858-1988
The aetiology of multiple sclerosis: 1883-1976
Attitudes to the treatment of multiple sclerosis: 1841-1983
SECTION TWO: THE CAUSE AND COURSE OF MULTIPLE SCLEROSIS
2. The distribution of multiple sclerosis
The rationale for epidemiological studies in multiple sclerosis
Definitions and statistics in epidemiology
Strategies for epidemiological studies in multiple sclerosis
The geography of multiple sclerosis
Epidemics and clusters of multiple sclerosis
The environmental factor in multiple sclerosis
3. The genetics of multiple sclerosis:
Genetic analysis of multiple sclerosis
Methods of genetic analysis
Racial susceptibility
Sex differences in susceptibility
Familial multiple sclerosis
Candidate genes in multiple sclerosis
Systematic genome screening
Lessons from genetic studies of experimental allergic encephalomyelitis
Conclusions
4. The natural history of multiple sclerosis
Introduction
Definitions
Onset
Course
Inter-individual variability
Factors affecting the prognosis
General considerations
Environmental influences
Chapter 5: The aetiology of multiple sclerosis: an epitome
SECTION THREE: THE CLINICAL FEATURES AND DIAGNOSIS OF MULTIPLE SCLEROSIS
6. The symptoms and signs of multiple sclerosis.
Multiple sclerosis as a neurological illness
Initial symptoms
Symptoms and signs in the course of the disease
Individual symptoms and sign
Associated diseases
Conclusion
7. The diagnosis of multiple sclerosis
Diagnostic criteria for multiple sclerosis
Selection of investigations
Magnetic resonance imaging
Evoked potentials
Examination of the cerebrospinal fluid
A strategy for the investigation of demyelinating disease
8. The differential diagnosis of multiple sclerosis
The spectrum of disorders mimicking multiple sclerosis
Diseases that may cause multiple lesions of the CNS and also often follow a relapsing remitting course
Systematized central nervous system diseases
Isolated or monosymptomatic CNS syndromes
Non organic symptoms
How accurate is the diagnosis of multiple sclerosis?
9. Multiple sclerosis in the individual and in groups: a conspectus
The typical case
Isolated syndromes and their outcome: judicious use of investigations and critique of the new diagnostic criteria
Co-morbidity and associated diseases
Situations in which alternative diagnoses should be considered
When to ignore "inconvenient laboratory results or clinical findings: taking the best position
"Pathognomonic and "un-heard of features of multiple sclerosis
SECTION FOUR: THE PATHOGENESIS OF MULTIPLE SCLEROSIS
10. The neurobiology of multiple sclerosis.
Organisation in the central nervous system
Development of the central nervous system
Macroglial lineages in the rodent and human nervous system
Axon-glial interactions and myelination
Demyelination
Axon degeneration and restoration of function
Remyelination
11. The immunology of inflammatory demyelinating disease
Multiple sclerosis as an autoimmune disease
Immune responses: innate and adaptive
T lymphocytes
B lymphocytes
Autoimmunity and self tolerance in the central nervous system
Regulation of central nervous system autoimmune responses
Immune reactivity in the central nervous system
Pathogenesis of demyelination and tissue damage
Peripheral blood biomarkers
1. The story of multiple sclerosis
The evolving concept of multiple sclerosis
Naming and classifying the disease: 1868-1983
Clinical descriptions of multiple sclerosis: 1838-1981
Personal accounts of multiple sclerosis: 1824-1991
The social history of multiple sclerosis: 1945-1998
The pathogenesis and clinical anatomy of multiple sclerosis: 1849-1977
The laboratory science of multiple sclerosis: 1912-1981
Discovery of glia and remyelination: 1858-1988
The aetiology of multiple sclerosis: 1883-1976
Attitudes to the treatment of multiple sclerosis: 1841-1983
SECTION TWO: THE CAUSE AND COURSE OF MULTIPLE SCLEROSIS
2. The distribution of multiple sclerosis
The rationale for epidemiological studies in multiple sclerosis
Definitions and statistics in epidemiology
Strategies for epidemiological studies in multiple sclerosis
The geography of multiple sclerosis
Epidemics and clusters of multiple sclerosis
The environmental factor in multiple sclerosis
3. The genetics of multiple sclerosis:
Genetic analysis of multiple sclerosis
Methods of genetic analysis
Racial susceptibility
Sex differences in susceptibility
Familial multiple sclerosis
Candidate genes in multiple sclerosis
Systematic genome screening
Lessons from genetic studies of experimental allergic encephalomyelitis
Conclusions
4. The natural history of multiple sclerosis
Introduction
Definitions
Onset
Course
Inter-individual variability
Factors affecting the prognosis
General considerations
Environmental influences
Chapter 5: The aetiology of multiple sclerosis: an epitome
SECTION THREE: THE CLINICAL FEATURES AND DIAGNOSIS OF MULTIPLE SCLEROSIS
6. The symptoms and signs of multiple sclerosis.
Multiple sclerosis as a neurological illness
Initial symptoms
Symptoms and signs in the course of the disease
Individual symptoms and sign
Associated diseases
Conclusion
7. The diagnosis of multiple sclerosis
Diagnostic criteria for multiple sclerosis
Selection of investigations
Magnetic resonance imaging
Evoked potentials
Examination of the cerebrospinal fluid
A strategy for the investigation of demyelinating disease
8. The differential diagnosis of multiple sclerosis
The spectrum of disorders mimicking multiple sclerosis
Diseases that may cause multiple lesions of the CNS and also often follow a relapsing remitting course
Systematized central nervous system diseases
Isolated or monosymptomatic CNS syndromes
Non organic symptoms
How accurate is the diagnosis of multiple sclerosis?
9. Multiple sclerosis in the individual and in groups: a conspectus
The typical case
Isolated syndromes and their outcome: judicious use of investigations and critique of the new diagnostic criteria
Co-morbidity and associated diseases
Situations in which alternative diagnoses should be considered
When to ignore "inconvenient laboratory results or clinical findings: taking the best position
"Pathognomonic and "un-heard of features of multiple sclerosis
SECTION FOUR: THE PATHOGENESIS OF MULTIPLE SCLEROSIS
10. The neurobiology of multiple sclerosis.
Organisation in the central nervous system
Development of the central nervous system
Macroglial lineages in the rodent and human nervous system
Axon-glial interactions and myelination
Demyelination
Axon degeneration and restoration of function
Remyelination
11. The immunology of inflammatory demyelinating disease
Multiple sclerosis as an autoimmune disease
Immune responses: innate and adaptive
T lymphocytes
B lymphocytes
Autoimmunity and self tolerance in the central nervous system
Regulation of central nervous system autoimmune responses
Immune reactivity in the central nervous system
Pathogenesis of demyelination and tissue damage
Peripheral blood biomarkers
SECTION ONE: THE STORY OF MULTIPLE SCLEROSIS
1. The story of multiple sclerosis
The evolving concept of multiple sclerosis
Naming and classifying the disease: 1868-1983
Clinical descriptions of multiple sclerosis: 1838-1981
Personal accounts of multiple sclerosis: 1824-1991
The social history of multiple sclerosis: 1945-1998
The pathogenesis and clinical anatomy of multiple sclerosis: 1849-1977
The laboratory science of multiple sclerosis: 1912-1981
Discovery of glia and remyelination: 1858-1988
The aetiology of multiple sclerosis: 1883-1976
Attitudes to the treatment of multiple sclerosis: 1841-1983
SECTION TWO: THE CAUSE AND COURSE OF MULTIPLE SCLEROSIS
2. The distribution of multiple sclerosis
The rationale for epidemiological studies in multiple sclerosis
Definitions and statistics in epidemiology
Strategies for epidemiological studies in multiple sclerosis
The geography of multiple sclerosis
Epidemics and clusters of multiple sclerosis
The environmental factor in multiple sclerosis
3. The genetics of multiple sclerosis:
Genetic analysis of multiple sclerosis
Methods of genetic analysis
Racial susceptibility
Sex differences in susceptibility
Familial multiple sclerosis
Candidate genes in multiple sclerosis
Systematic genome screening
Lessons from genetic studies of experimental allergic encephalomyelitis
Conclusions
4. The natural history of multiple sclerosis
Introduction
Definitions
Onset
Course
Inter-individual variability
Factors affecting the prognosis
General considerations
Environmental influences
Chapter 5: The aetiology of multiple sclerosis: an epitome
SECTION THREE: THE CLINICAL FEATURES AND DIAGNOSIS OF MULTIPLE SCLEROSIS
6. The symptoms and signs of multiple sclerosis.
Multiple sclerosis as a neurological illness
Initial symptoms
Symptoms and signs in the course of the disease
Individual symptoms and sign
Associated diseases
Conclusion
7. The diagnosis of multiple sclerosis
Diagnostic criteria for multiple sclerosis
Selection of investigations
Magnetic resonance imaging
Evoked potentials
Examination of the cerebrospinal fluid
A strategy for the investigation of demyelinating disease
8. The differential diagnosis of multiple sclerosis
The spectrum of disorders mimicking multiple sclerosis
Diseases that may cause multiple lesions of the CNS and also often follow a relapsing remitting course
Systematized central nervous system diseases
Isolated or monosymptomatic CNS syndromes
Non organic symptoms
How accurate is the diagnosis of multiple sclerosis?
9. Multiple sclerosis in the individual and in groups: a conspectus
The typical case
Isolated syndromes and their outcome: judicious use of investigations and critique of the new diagnostic criteria
Co-morbidity and associated diseases
Situations in which alternative diagnoses should be considered
When to ignore "inconvenient laboratory results or clinical findings: taking the best position
"Pathognomonic and "un-heard of features of multiple sclerosis
SECTION FOUR: THE PATHOGENESIS OF MULTIPLE SCLEROSIS
10. The neurobiology of multiple sclerosis.
Organisation in the central nervous system
Development of the central nervous system
Macroglial lineages in the rodent and human nervous system
Axon-glial interactions and myelination
Demyelination
Axon degeneration and restoration of function
Remyelination
11. The immunology of inflammatory demyelinating disease
Multiple sclerosis as an autoimmune disease
Immune responses: innate and adaptive
T lymphocytes
B lymphocytes
Autoimmunity and self tolerance in the central nervous system
Regulation of central nervous system autoimmune responses
Immune reactivity in the central nervous system
Pathogenesis of demyelination and tissue damage
Peripheral blood biomarkers
1. The story of multiple sclerosis
The evolving concept of multiple sclerosis
Naming and classifying the disease: 1868-1983
Clinical descriptions of multiple sclerosis: 1838-1981
Personal accounts of multiple sclerosis: 1824-1991
The social history of multiple sclerosis: 1945-1998
The pathogenesis and clinical anatomy of multiple sclerosis: 1849-1977
The laboratory science of multiple sclerosis: 1912-1981
Discovery of glia and remyelination: 1858-1988
The aetiology of multiple sclerosis: 1883-1976
Attitudes to the treatment of multiple sclerosis: 1841-1983
SECTION TWO: THE CAUSE AND COURSE OF MULTIPLE SCLEROSIS
2. The distribution of multiple sclerosis
The rationale for epidemiological studies in multiple sclerosis
Definitions and statistics in epidemiology
Strategies for epidemiological studies in multiple sclerosis
The geography of multiple sclerosis
Epidemics and clusters of multiple sclerosis
The environmental factor in multiple sclerosis
3. The genetics of multiple sclerosis:
Genetic analysis of multiple sclerosis
Methods of genetic analysis
Racial susceptibility
Sex differences in susceptibility
Familial multiple sclerosis
Candidate genes in multiple sclerosis
Systematic genome screening
Lessons from genetic studies of experimental allergic encephalomyelitis
Conclusions
4. The natural history of multiple sclerosis
Introduction
Definitions
Onset
Course
Inter-individual variability
Factors affecting the prognosis
General considerations
Environmental influences
Chapter 5: The aetiology of multiple sclerosis: an epitome
SECTION THREE: THE CLINICAL FEATURES AND DIAGNOSIS OF MULTIPLE SCLEROSIS
6. The symptoms and signs of multiple sclerosis.
Multiple sclerosis as a neurological illness
Initial symptoms
Symptoms and signs in the course of the disease
Individual symptoms and sign
Associated diseases
Conclusion
7. The diagnosis of multiple sclerosis
Diagnostic criteria for multiple sclerosis
Selection of investigations
Magnetic resonance imaging
Evoked potentials
Examination of the cerebrospinal fluid
A strategy for the investigation of demyelinating disease
8. The differential diagnosis of multiple sclerosis
The spectrum of disorders mimicking multiple sclerosis
Diseases that may cause multiple lesions of the CNS and also often follow a relapsing remitting course
Systematized central nervous system diseases
Isolated or monosymptomatic CNS syndromes
Non organic symptoms
How accurate is the diagnosis of multiple sclerosis?
9. Multiple sclerosis in the individual and in groups: a conspectus
The typical case
Isolated syndromes and their outcome: judicious use of investigations and critique of the new diagnostic criteria
Co-morbidity and associated diseases
Situations in which alternative diagnoses should be considered
When to ignore "inconvenient laboratory results or clinical findings: taking the best position
"Pathognomonic and "un-heard of features of multiple sclerosis
SECTION FOUR: THE PATHOGENESIS OF MULTIPLE SCLEROSIS
10. The neurobiology of multiple sclerosis.
Organisation in the central nervous system
Development of the central nervous system
Macroglial lineages in the rodent and human nervous system
Axon-glial interactions and myelination
Demyelination
Axon degeneration and restoration of function
Remyelination
11. The immunology of inflammatory demyelinating disease
Multiple sclerosis as an autoimmune disease
Immune responses: innate and adaptive
T lymphocytes
B lymphocytes
Autoimmunity and self tolerance in the central nervous system
Regulation of central nervous system autoimmune responses
Immune reactivity in the central nervous system
Pathogenesis of demyelination and tissue damage
Peripheral blood biomarkers