Novartis Foundation, Johannes D. Veldhuis

Mechanisms and Biological Significance of Pulsatile Hormone Secretion

Ed. by Derek J. Chadwick and Jamie A. Goode

• Gebundenes Buch

Produktbeschreibung

Dieses Buch beschäftigt sich mit grundlegenden Mechanismen der zeitlichen Steuerung unseres Organismus, die den circadianen und den jahreszeitlichen Lebensrhythmus bestimmen. Diskutiert werden die wichtigsten Peptidhormonsysteme, die Bedeutung der Rhythmen hinsichtlich verschiedener Chemotherapien, die Pathologie des Circadianrhythmus und Veränderungen im Laufe der Alterung des Organismus. In vertebrates, the endocrine system plays a key role in conveying environmental temporal information to changes in physiology. This book reviews the biological basis of pulsatile hormone release, exploring the current state of knowledge of pulsatile hormone secretion in health and disease.

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Produktdetails

• Novartis Foundation Symposium
• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 280
• Erscheinungstermin: 7. April 2000
• Englisch
• Abmessung: 239mm x 159mm x 19mm
• Gewicht: 564g
• ISBN-13: 9780471999188
• ISBN-10: 0471999180
• Artikelnr.: 09463992

Autorenporträt

Derek J. Chadwick and Jamie A. Goode are editors for Mechanisms and Biological Significance of Pulsatile Hormone Secretion and other scientific titles.

Inhaltsangabe

Introduction (J. Veldhuis).
Rhythmic Transcription: The Molecular Basis of Oscillatory Melatonin
Synthesis (N. Foulkes, et al.).
The Frequency Encoding of Pulsatility (A. Goldbeter, et al.).
Timing-Dependent Modulation of Insulin Mitogenic Versus Metabolic
Signalling (P. De Meyts & R. Shymko).
Growth Hormone Pulse-Activated STAT5 Signalling: A Unique Regulatory
Mechanism Governing Sexual
Dimorphism of Liver Gene Expression (D. Waxman).
Orderliness of Hormone Release (S. Pincus).
Prediction and Significance of the Temporal Pattern of Hormone Secretion in
Disease States (G. Brabant & K.
Prank).
Therapeutic Implications of Circadian Rhythms in Cancer Patients (F. Lévi).
Pathophysiology of Human Circadian Rhythms (G. Copinschi, et al.).
Nature of Altered Pulsatile Hormone Release and Neuroendocrine Network
Signalling in Human Ageing: Clinical
Studies of the Somatotropic, Gonadotropic, Corticotropic and Insulin Axes
(J. Veldhuis).
Pulsatile Insulin Secretion (P. Butler).
Control of Growth Hormone (GH) release by GH Secretagogues (I. Robinson).
Pulsatile Parathyroid Hormone Secretion in Health and Disease (F.
Schaefer).
Significance of Pulsatility in the HPA Axis (S. Lightman, et al.).
Closing Remarks (J. Veldhuis).
Indexes.

Rezensionen

"This book provides a comprehensive and excellent summary of our state of knowledge,"
(Cell Biology International, May 2001)

"This outstanding text should stimulate further research on pulsatile hormone secretion that will enhance both biomedical science and clinical treatments of hormone-related disorders"
(Trends in Endocrinology & Metabolism, August 2001)