Mechanisms of Altered Hepatotoxicity in Nonalcoholic Fatty Liver - donthamsetty, shashikiran
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The objectives of this research were to investigate 1) if hepatic steatosis and nonalcoholic steatohepatitis (NASH) independently sensitize the liver to hepatotoxicity and 2) the mechanisms behind the increased sensitivity.Our study suggests that fatty hepatocytes fail to undergo compensatory cell division rendering the liver susceptible to progressive expansion of liver injury. In conclusion, impaired tissue repair response sensitizes the steatotic/steatohepatitic livers to hepatotoxicity.

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Produktbeschreibung
The objectives of this research were to investigate 1) if hepatic steatosis and nonalcoholic steatohepatitis (NASH) independently sensitize the liver to hepatotoxicity and 2) the mechanisms behind the increased sensitivity.Our study suggests that fatty hepatocytes fail to undergo compensatory cell division rendering the liver susceptible to progressive expansion of liver injury. In conclusion, impaired tissue repair response sensitizes the steatotic/steatohepatitic livers to hepatotoxicity.
Autorenporträt
Shashikiran Donthamsetty joined the Department of Toxicology at the University of Louisiana at Monroe, Monroe, USA in fall 2003, to pursue a Ph.D. in Toxicology under Dr. Harihara Mehendale¿s mentorship. Shashi is currently pursuing his postdoctoral training with Dr. George Michalapoulos at Pittsburgh Medical Centre, Pittsburg, PA.