It is less than 80 years since John Newport Langley first proposed the role of "receptive substances" as the site of drug action from his obser vations on the effects of nicotine and curare at the myoneural junction. The many advances in our understanding of receptor biology that have occurred during the intervening period mirror the extraordinary growth of knowledge in the biological sciences and in cell and molecular biology in particular. Receptor biology, in common with many other topics in contemporary biology, is on the threshold of a transition from being a descriptive,…mehr
It is less than 80 years since John Newport Langley first proposed the role of "receptive substances" as the site of drug action from his obser vations on the effects of nicotine and curare at the myoneural junction. The many advances in our understanding of receptor biology that have occurred during the intervening period mirror the extraordinary growth of knowledge in the biological sciences and in cell and molecular biology in particular. Receptor biology, in common with many other topics in contemporary biology, is on the threshold of a transition from being a descriptive, phenomenological discipline to one in which underlying mechanisms and regulatory principles can be defined with increasing pre cision. This change, together with the evolution of powerful analytical techniques and timely convergence of ideas from a number of previously separate fields of inquiry, is generating an increasingly unified theoretical and experimental framework for the study of receptor function. These themes, and the mood of anticipation that a real understanding of receptor function in health and disease is emerging, are reflected in in this volume, which summarizes the proceedings of the Sec the papers ond Smith Kline & French Research Symposium on New Horizons in Therapeutics held in Philadelphia in 1984.
1 Receptor Regulation: Problems and Perspectives.- 1. Introduction.- 2. Receptor Regulation.- 3. Insulin Receptor Studies.- 4. Conclusion.- References.- 2 Patterns in Receptor Behavior and Function.- 1. Introduction.- 2. Class I Receptors.- 3. Class II Receptors.- 4. Recycling and the Endosome.- 5. Role of the Endosome in Regulating Cell Surface Area.- References.- 3 The Membrane Receptors of Epidermal Growth Factor: Structural and Functional Studies.- 1. Introduction.- 2. Results.- 2.1. Purification of EGF Receptor by Immunoaffinity Chromatography.- 2.2. Structural Domains on EGF Receptor: Analysis with Immunologic Probes.- 3. Discussion.- 4. Concluding Remarks.- References.- 4 The Insulin Receptor as a Tyrosine-Specific Protein Kinase.- 1. Introduction.- 2. Development of a Monoclonal Antibody to the Human Placental Insulin Receptor.- 3. Purification of the Insulin-Dependent Protein Kinase from Human Placenta.- 4. Properties of the Purified Human Placental Insulin-Dependent Protein Kinase.- 5. Substrates for the Insulin-Dependent Protein Kinase.- 5.1. Peptides.- 5.2. Proteins.- 6. Properties of the Phosphoreceptor: Consequences of Reversible Autophosphorylation.- 7. Insulin-Promoted Phosphorylation in 3T3-L1 Adipocytes.- 8. Concluding Remarks.- References.- 5 Signal Transduction in Biological Membranes.- 1. Information Processing: Some Generalities.- 2. Transduction and the Adenylate Cyclase System.- 3. GTP Binding Proteins: A Family of Membrane Regulatory Proteins.- 4. Organization of Receptors and Transduction Elements in Membranes.- 5. Summary.- References.- 6 Receptor-Controlled Phosphatidylinositol 4,5-Bisphosphate Hydrolysis in the Control of Rapid Receptor-Mediated Cellular Responses and of Cellular Proliferation.- 1. Introduction.- 2. "V1 Vasopressin Receptors": Receptors for Hormone or Neurotransmitter.- 3. Phosphatidylinositol 4,5-Bisphosphate Hydrolysis as a Coupling Reaction in Receptor-Mediated Signaling.- 4. Stimulated Inositol Lipid Metabolism and Cell Proliferation.- References.- 7 Requirements for Steroid Hormone Action in Eucaryotic Cells.- 1. Introduction.- 2. Receptors for Progesterone.- 3. Postreceptor Specificity.- 4. Induction of Transcription.- 5. Tissue-Specific Factors.- 6. Role of the Nuclear Matrix.- 7. Conclusions.- References.- 8 Inositol Trisphosphate and Diacylglycerol as Intracellular Second Messengers.- 1. Introduction.- 2. Formation of Diacylglycerol and Inositol Trisphosphate.- 3. Removal of Diacylglycerol and Inositol Trisphosphate.- 4. Mode of Action of Diacylglycerol and Inositol Trisphosphate.- 5. Functional Interactions between Diacylglycerol and Calcium.- 6. Oncogenes and Phosphoinositide Metabolism.- 7. Phosphoinositide Levels and Receptor Sensitivity.- References.- 9 Ionic Signal Transduction by Growth Factors.- 1. Introduction.- 2. Monovalent Ions in Growth Factor Action.- 2.1. Rapid Electrical Events.- 2.2. The Na+-K+ Pump and Na+-H+ Exchange.- 2.3. Changes in Cytoplasmic Ph.- 2.4. Metabolic Effects of a Rise in pHi.- 3. Calcium Mobilization by Growth Factors.- 4. Concluding Remarks.- References.- 10 Guanine-Nucleotide-Binding Regulatory Proteins: Membrane-Bound Information Transducers.- 1. Introduction.- 2. The G-Protein Family.- 3. Regulation of Adenylate Cyclase Activity by Gs and Gi.- 4. Speculations.- References.- 11 Role of Cyclic-AMP-Dependent Protein Kinase in the Regulation of Cellular Processes.- 1. Criteria for Evaluating the Role of Protein Phosphorylation in Cyclic-AMP-Mediated Processes.- 2. Additional Approaches.- 2.1. Measurement of the Activity of Cyclic-AMP-Dependent Protein Kinases in Vivo.- 2.2. Introduction of Kinase Subunits into Cells.- 2.3. Stoichiometry of Protein Phosphorylations.- 3. Selected Examples of Cyclic-AMP-Mediated Protein Phosphorylation.- 3.1. Skeletal Muscle Phosphorylase Kinase.- 3.2. Cyclic-AMP-Dependent Phosphorylation of Smooth Muscle Myosin Light-Chain Kinase.- 3.3. Activation of Tyrosine Hydroxylase by Neuronal Depolarization.- 3.4
1 Receptor Regulation: Problems and Perspectives.- 1. Introduction.- 2. Receptor Regulation.- 3. Insulin Receptor Studies.- 4. Conclusion.- References.- 2 Patterns in Receptor Behavior and Function.- 1. Introduction.- 2. Class I Receptors.- 3. Class II Receptors.- 4. Recycling and the Endosome.- 5. Role of the Endosome in Regulating Cell Surface Area.- References.- 3 The Membrane Receptors of Epidermal Growth Factor: Structural and Functional Studies.- 1. Introduction.- 2. Results.- 2.1. Purification of EGF Receptor by Immunoaffinity Chromatography.- 2.2. Structural Domains on EGF Receptor: Analysis with Immunologic Probes.- 3. Discussion.- 4. Concluding Remarks.- References.- 4 The Insulin Receptor as a Tyrosine-Specific Protein Kinase.- 1. Introduction.- 2. Development of a Monoclonal Antibody to the Human Placental Insulin Receptor.- 3. Purification of the Insulin-Dependent Protein Kinase from Human Placenta.- 4. Properties of the Purified Human Placental Insulin-Dependent Protein Kinase.- 5. Substrates for the Insulin-Dependent Protein Kinase.- 5.1. Peptides.- 5.2. Proteins.- 6. Properties of the Phosphoreceptor: Consequences of Reversible Autophosphorylation.- 7. Insulin-Promoted Phosphorylation in 3T3-L1 Adipocytes.- 8. Concluding Remarks.- References.- 5 Signal Transduction in Biological Membranes.- 1. Information Processing: Some Generalities.- 2. Transduction and the Adenylate Cyclase System.- 3. GTP Binding Proteins: A Family of Membrane Regulatory Proteins.- 4. Organization of Receptors and Transduction Elements in Membranes.- 5. Summary.- References.- 6 Receptor-Controlled Phosphatidylinositol 4,5-Bisphosphate Hydrolysis in the Control of Rapid Receptor-Mediated Cellular Responses and of Cellular Proliferation.- 1. Introduction.- 2. "V1 Vasopressin Receptors": Receptors for Hormone or Neurotransmitter.- 3. Phosphatidylinositol 4,5-Bisphosphate Hydrolysis as a Coupling Reaction in Receptor-Mediated Signaling.- 4. Stimulated Inositol Lipid Metabolism and Cell Proliferation.- References.- 7 Requirements for Steroid Hormone Action in Eucaryotic Cells.- 1. Introduction.- 2. Receptors for Progesterone.- 3. Postreceptor Specificity.- 4. Induction of Transcription.- 5. Tissue-Specific Factors.- 6. Role of the Nuclear Matrix.- 7. Conclusions.- References.- 8 Inositol Trisphosphate and Diacylglycerol as Intracellular Second Messengers.- 1. Introduction.- 2. Formation of Diacylglycerol and Inositol Trisphosphate.- 3. Removal of Diacylglycerol and Inositol Trisphosphate.- 4. Mode of Action of Diacylglycerol and Inositol Trisphosphate.- 5. Functional Interactions between Diacylglycerol and Calcium.- 6. Oncogenes and Phosphoinositide Metabolism.- 7. Phosphoinositide Levels and Receptor Sensitivity.- References.- 9 Ionic Signal Transduction by Growth Factors.- 1. Introduction.- 2. Monovalent Ions in Growth Factor Action.- 2.1. Rapid Electrical Events.- 2.2. The Na+-K+ Pump and Na+-H+ Exchange.- 2.3. Changes in Cytoplasmic Ph.- 2.4. Metabolic Effects of a Rise in pHi.- 3. Calcium Mobilization by Growth Factors.- 4. Concluding Remarks.- References.- 10 Guanine-Nucleotide-Binding Regulatory Proteins: Membrane-Bound Information Transducers.- 1. Introduction.- 2. The G-Protein Family.- 3. Regulation of Adenylate Cyclase Activity by Gs and Gi.- 4. Speculations.- References.- 11 Role of Cyclic-AMP-Dependent Protein Kinase in the Regulation of Cellular Processes.- 1. Criteria for Evaluating the Role of Protein Phosphorylation in Cyclic-AMP-Mediated Processes.- 2. Additional Approaches.- 2.1. Measurement of the Activity of Cyclic-AMP-Dependent Protein Kinases in Vivo.- 2.2. Introduction of Kinase Subunits into Cells.- 2.3. Stoichiometry of Protein Phosphorylations.- 3. Selected Examples of Cyclic-AMP-Mediated Protein Phosphorylation.- 3.1. Skeletal Muscle Phosphorylase Kinase.- 3.2. Cyclic-AMP-Dependent Phosphorylation of Smooth Muscle Myosin Light-Chain Kinase.- 3.3. Activation of Tyrosine Hydroxylase by Neuronal Depolarization.- 3.4
Es gelten unsere Allgemeinen Geschäftsbedingungen: www.buecher.de/agb
Impressum
www.buecher.de ist ein Shop der buecher.de GmbH & Co. KG Bürgermeister-Wegele-Str. 12, 86167 Augsburg Amtsgericht Augsburg HRA 13309