Incorporating recent advances in molecular biology and examining cellular and molecular mechanisms with regard to toxic effects, this second edition features new chapters on types of toxic responses, novel mechanisms derived from systems toxicology, and disruption of cellular signal transduction. Expanded chapters include the disruption of mitochondrial function, mitochondrial outer membrane permeabilization, and selective depletion of mitochondrial DNA. The book links molecular and cellular biology with xenobiotic toxicology and contains new examples and illustrations to supplement material.…mehr
Incorporating recent advances in molecular biology and examining cellular and molecular mechanisms with regard to toxic effects, this second edition features new chapters on types of toxic responses, novel mechanisms derived from systems toxicology, and disruption of cellular signal transduction. Expanded chapters include the disruption of mitochondrial function, mitochondrial outer membrane permeabilization, and selective depletion of mitochondrial DNA. The book links molecular and cellular biology with xenobiotic toxicology and contains new examples and illustrations to supplement material. Additional topics include oxidant stress, apoptotic and necrotic cell death, nuclear-receptor-mediated toxicity, and immune-mediated toxicity.
Introduction Types of Toxic Responses Organ-Selective Toxicity Cellular Transport and Selective Accumulation of Potentially Toxic Xenobiotics Bioactivation of Xenobiotics to Reactive Metabolites Xenobiotic-Induced Oxidative Stress: Cell Injury Signaling and Gene Regulation Disruption of Cellular Calcium Homeostasis Mechanisms of Necrotic and Apoptotic Cell Death Impairment of Cell Proliferation and Tissue Repair Covalent Binding of Reactive Metabolites to Cellular Macromolecules Immune Mechanisms Cytokine-Mediated Toxicity Specific Inactivation of Enzymes and Other Proteins Interactions of Xenobiotics with Ion Transporters Nuclear Receptor-Mediated Toxicity Activation or Disruption of Cellular Signal Transduction by Xenobiotics Disruption of Mitochondrial Function and Mitochondria-Mediated Toxicity Novel Mechanisms Derived from Systems Toxicology Index
Introduction Types of Toxic Responses Organ-Selective Toxicity Cellular Transport and Selective Accumulation of Potentially Toxic Xenobiotics Bioactivation of Xenobiotics to Reactive Metabolites Xenobiotic-Induced Oxidative Stress: Cell Injury Signaling and Gene Regulation Disruption of Cellular Calcium Homeostasis Mechanisms of Necrotic and Apoptotic Cell Death Impairment of Cell Proliferation and Tissue Repair Covalent Binding of Reactive Metabolites to Cellular Macromolecules Immune Mechanisms Cytokine-Mediated Toxicity Specific Inactivation of Enzymes and Other Proteins Interactions of Xenobiotics with Ion Transporters Nuclear Receptor-Mediated Toxicity Activation or Disruption of Cellular Signal Transduction by Xenobiotics Disruption of Mitochondrial Function and Mitochondria-Mediated Toxicity Novel Mechanisms Derived from Systems Toxicology Index
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