Urs a Boelsterli

Mechanistic Toxicology

The Molecular Basis of How Chemicals Disrupt Biological Targets

• Broschiertes Buch

Produktbeschreibung

Incorporating recent advances in molecular biology and examining cellular and molecular mechanisms with regard to toxic effects, this second edition features new chapters on types of toxic responses, novel mechanisms derived from systems toxicology, and disruption of cellular signal transduction. Expanded chapters include the disruption of mitochondrial function, mitochondrial outer membrane permeabilization, and selective depletion of mitochondrial DNA. The book links molecular and cellular biology with xenobiotic toxicology and contains new examples and illustrations to supplement material. Additional topics include oxidant stress, apoptotic and necrotic cell death, nuclear-receptor-mediated toxicity, and immune-mediated toxicity.

Produktdetails

• Verlag: Longman Publishing Group
• 2nd edition
• Seitenzahl: 416
• Erscheinungstermin: 1. April 2007
• Englisch
• Abmessung: 238mm x 166mm x 28mm
• Gewicht: 703g
• ISBN-13: 9780849372728
• ISBN-10: 0849372720
• Artikelnr.: 20995448

Autorenporträt

Urs A. Boelsterli

Inhaltsangabe

Introduction
Types of Toxic Responses
Organ-Selective Toxicity
Cellular Transport and Selective Accumulation of Potentially Toxic Xenobiotics
  Bioactivation of Xenobiotics to Reactive Metabolites
Xenobiotic-Induced Oxidative Stress: Cell Injury
Signaling
and Gene Regulation
Disruption of Cellular Calcium Homeostasis
Mechanisms of Necrotic and Apoptotic Cell Death
  Impairment of Cell Proliferation and Tissue Repair
Covalent Binding of Reactive Metabolites to Cellular Macromolecules
Immune Mechanisms
Cytokine-Mediated Toxicity
Specific Inactivation of Enzymes and Other Proteins
Interactions of Xenobiotics with Ion Transporters
Nuclear Receptor-Mediated Toxicity
Activation or Disruption of Cellular Signal Transduction by Xenobiotics
Disruption of Mitochondrial Function and Mitochondria-Mediated Toxicity
Novel Mechanisms Derived from Systems Toxicology
Index