Mechanotransduction

Volume 126
Herausgegeben:Engler, Adam J.; Kumar, Sanjay

• Gebundenes Buch

Produktbeschreibung

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.

Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction.

Produktdetails

• Progress in Molecular Biology and Translational Science Volume 126
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: C2011-0-07845-6
• Seitenzahl: 384
• Erscheinungstermin: 23. Juli 2014
• Englisch
• Abmessung: 238mm x 159mm x 25mm
• Gewicht: 752g
• ISBN-13: 9780123946249
• ISBN-10: 0123946247
• Artikelnr.: 40919993

Autorenporträt

Sanjay Kumar is Associate Professor of Bioengineering, Chair of the UC Berkeley & UCSF Graduate Program at UC Berkeley, Faculty Scientist at Lawrence Berkeley National Laboratory and Faculty Director of the UC Berkeley & UCSF Master of Translational Medicine Program. He earned a B.S. in chemical engineering (1996) from the University of Minnesota and then moved on to Johns Hopkins University, where he earned an M.D. (2003) and a Ph.D. in molecular biophysics (2003). Since joining the UC Berkeley faculty in 2005, Dr. Kumar has been fortunate to receive a number of honors, including the Presidential Early Career Award for Scientists and Engineers (PECASE), The NIH Director's New Innovator Award, The Arnold and Mabel Beckman Young Investigator Award, the NSF CAREER Award, the Hellman Family Faculty Fund Award, and the Stem Cells Young Investigator Award.

Inhaltsangabe

Subcellular tools for activating and measuring mechanotransductive signaling

1. The Detection and Role of Molecular Tension in Focal Adhesion DynamicsBrenton D. Hoffman2. Single Cell Imaging of Mechanotransduction in Endothelial CellsShaoying Lu and Yingxiao Wang

Focal adhesions as sensors

3. Focal Adhesions as SensorsJean-Cheng Kuo4. Focal Adhesions as SensorsWolfgang H. Goldmann5. Mechanical Cues Direct Focal Adhesion DynamicsKristina Haase, Zeinab Al-Rekabi and Andrew E. Pelling6. Molecular Mechanisms Underlying the Force-Dependent Regulation of Actin-to-ECM Linkage at the Focal AdhesionsHiroaki Hirata, Masahiro Sokabe and Chwee Teck Lim

Nuclear Mechanisms of Sensing

7. The Cellular Mastermind(?) - Mechanotransduction and the NucleusAshley Kaminski, Gregory R. Fedorchak and Jan Lammerding8. Nuclear Forces and Cell Mechano-SensingSamer Alam, David B. Lovett, Richard B. Dickinson, Kyle J. Roux and Tanmay P. Lele

Mechano-sensing in Stem Cells

9. From Stem Cells to Cardiomyocytes: The Role of Forces in Cardiac Maturation, Aging, and DiseaseGaurav Kaushik and Adam J. Engler10. Matrix Regulation of Tumor-Initiating CellsSophie Y. Wong and Sanjay Kumar11. Biomaterials Approaches in Stem Cell MechanobiologyNikolche Gjorevski and Matthias Lutolf

Multi-cellular Sensing

12. Mechanotransduction in C. elegans Morphogenesis and Tissue FunctionErin J. Cram13. Mechanical Force Sensing in TissuesSoline Chanet and Adam C. Martin

Rezensionen

Praise for the series:"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal