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This is a community survey of how Sickle Cell Anaemia (SCA) is conceived, managed as well as the influence of the duo on one another. The study has broad objective of elucidating the social and cultural constructs of SCA and the dynamics of its management process. The expectations here included the understanding of how social and cultural constructs facilitates the appreciation of perceptions and various medical responses to this medical condition and what should be done to enhance a workable intervention policy on positive behavioural change for effective management approaches among the people. To achieve this, the study made use of both Quantitative and Qualitative methods to collect data among the Sickle cell patients, primary caregivers, the secondary caregivers (health workers at the clinics, the traditional and faith healers) and the general populace at the study sites.