The Handbook will standardize the management of toxicological emergencies by toxidromic approach, and impart basic competence in emergency & ICU care of poisoned/ overdosed/ envenomed cases, by systematic assessment, basic and advanced life support skills, resuscitation efforts, and team-based approach to clinical management in simulated scenarios. The reader can use this as handy guide for learning toxicology on High Fidelity Mannikins, based on Latest Clinical Updates and Current Recommendations by Indian Society of Toxicology.