Medicinal Chemistry and Drug Development describes the key events and roles of medicinal chemistry in the discovery and development of lead compounds into drugs, including target identification, which is accomplished by using 30 case studies. This book outlines all the stages of drug development, including the discovery of active compounds, research on the pharmacological properties of molecules, and confirmation of drug targets. The role of the case studies is to show the common factors in the successful development of drugs, thereby showing medicinal chemists how best to explore the…mehr
Medicinal Chemistry and Drug Development describes the key events and roles of medicinal chemistry in the discovery and development of lead compounds into drugs, including target identification, which is accomplished by using 30 case studies. This book outlines all the stages of drug development, including the discovery of active compounds, research on the pharmacological properties of molecules, and confirmation of drug targets. The role of the case studies is to show the common factors in the successful development of drugs, thereby showing medicinal chemists how best to explore the scientific pathways when developing new drugs. This makes the book especially relevant for senior university students majoring in pharmaceutical sciences as well as graduate students and researchers.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
1. Medicinal chemistry and process development of the type 2 diabetes drug sitagliptin 2. The developmental history of insulin pharmaceuticals 3. The developmental trajectory of GLP-1 receptor agonists 4. Antidiabetic drugs based on sodium-glucose cotransporter 2 inhibitors 5. Cholesterol-lowering drug atorvastatin 6. Angiotensin II receptor antagonists for treatment of hypertension: the discovery of losartan and its analogs 7. Antithrombotic drug-apixaban 8. Development of the anticoagulant drug fondaparinux sodium 9. Development of the nucleotide antiviral drug sofosbuvir for the hepatitis C virus 10. The first HIV-1 integrase inhibitor, raltegravir 11. Discovery and development of the human immunodeficiency virus protease inhibitor Saquinavir 12. Baloxavir: an antiinfluenza drug with a novel mechanism of action 13. Paclitaxel: a natural antitumor agent 14. Antitumor drug eribulin 15. Targeted protein kinase inhibitor imatinib 16. A case study of the irreversible covalent epidermal growth factor receptor (EGFR) inhibitor-afatinib 17. Medicinal chemistry and process development of the antibreast cancer drug tamoxifen 18. Triazole antifungal drug-fluconazole 19. Discovery of the antibacterial drug Linezolid and its synthetic technology research 20. Carbapenem antibiotic meropenem 21. Antiparasitic drug praziquantel 22. A case study on the proton pump inhibitor omeprazole 23. The inhibitors of phosphodiesterase type 5A effectively treat erectile dysfunction 24. GABAA receptor agonists: discovery of the general anesthetic propofol and its analogs 25. The discovery of risperidone: a case of multiple target antipsychotic drug 26. A case study on the first-in-class antirenal anemia drug roxadustat 27. Function, pharmaceutical, and pharmacological research and development of natural tetracyclic dipyranocoumarin (1)-calanolide A and its analogs 28. Bisphosphonates: a targeted therapeutic medication for skeletal system 29. Celecoxib targets cyclooxygenase in nonsteroidal antiinflammatory drugs 30. Case study of antisense oligonucleotides for duchenne muscular dystrophy
1. Medicinal chemistry and process development of the type 2 diabetes drug sitagliptin 2. The developmental history of insulin pharmaceuticals 3. The developmental trajectory of GLP-1 receptor agonists 4. Antidiabetic drugs based on sodium-glucose cotransporter 2 inhibitors 5. Cholesterol-lowering drug atorvastatin 6. Angiotensin II receptor antagonists for treatment of hypertension: the discovery of losartan and its analogs 7. Antithrombotic drug-apixaban 8. Development of the anticoagulant drug fondaparinux sodium 9. Development of the nucleotide antiviral drug sofosbuvir for the hepatitis C virus 10. The first HIV-1 integrase inhibitor, raltegravir 11. Discovery and development of the human immunodeficiency virus protease inhibitor Saquinavir 12. Baloxavir: an antiinfluenza drug with a novel mechanism of action 13. Paclitaxel: a natural antitumor agent 14. Antitumor drug eribulin 15. Targeted protein kinase inhibitor imatinib 16. A case study of the irreversible covalent epidermal growth factor receptor (EGFR) inhibitor-afatinib 17. Medicinal chemistry and process development of the antibreast cancer drug tamoxifen 18. Triazole antifungal drug-fluconazole 19. Discovery of the antibacterial drug Linezolid and its synthetic technology research 20. Carbapenem antibiotic meropenem 21. Antiparasitic drug praziquantel 22. A case study on the proton pump inhibitor omeprazole 23. The inhibitors of phosphodiesterase type 5A effectively treat erectile dysfunction 24. GABAA receptor agonists: discovery of the general anesthetic propofol and its analogs 25. The discovery of risperidone: a case of multiple target antipsychotic drug 26. A case study on the first-in-class antirenal anemia drug roxadustat 27. Function, pharmaceutical, and pharmacological research and development of natural tetracyclic dipyranocoumarin (1)-calanolide A and its analogs 28. Bisphosphonates: a targeted therapeutic medication for skeletal system 29. Celecoxib targets cyclooxygenase in nonsteroidal antiinflammatory drugs 30. Case study of antisense oligonucleotides for duchenne muscular dystrophy
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