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The present book describes the structure, spectral data, synthetic methods of preparation and chemical properties of 1,3,4-oxadiazoles. A description of diverse biological activities exhibited by the medicinally important compounds containing 1,3,4-oxadiazole nucleus is also given. Undoubtedly, this book will be beneficial for the researchers in the field of medicinal chemistry who wish to explore their research work in the development of medicinally active novel compounds bearing 1,3,4-oxdiazole nucleus.