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This book will be helpful to post-graduate and research scholar at the beginning of their research carrier. This includes general information, method of synthesis, reaction and medicinal activity of 1,3,4-thiadiazole.The medicinal activity of 1,3,4-thiadiazole has been described along with brief literature and active compounds of particular biological activities such as antimicrobial, anticancer, anti-inflammatory and analgesic, anticonvulsant etc.