Medicinal Chemistry of Neglected and Tropical Diseases

Advances in the Design and Synthesis of Antimicrobial Agents
Herausgeber: Castagnolo, Daniele; Özkay, Yusuf; Jayaprakash, Venkatesan

• Gebundenes Buch

Produktbeschreibung

The book focuses on medicinal chemistry research into developing effective drugs for the treatment of Neglected Tropical Diseases. The challenge of developing novel drugs and countering resistance to the available drugs requires indepth & updated knowledge on the subject area which this book is aimed at providing for an enthusiastic researcher.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 382
• Erscheinungstermin: 29. August 2019
• Englisch
• Abmessung: 260mm x 183mm x 25mm
• Gewicht: 914g
• ISBN-13: 9781138541245
• ISBN-10: 1138541249
• Artikelnr.: 57600092

Autorenporträt

Dr. Venkatesan Jayaprakash graduated (B. Pharmacy) from Madras Medical College, Madras in Pharmaceutical Sciences. He did his post graduation (M. Pharmacy) in Pharmaceutical Chemistry from Banaras Hindu University, Varanasi. He received his Ph.D. from Birla Institute of Technology, Mesra. Since 2004, he is working as a faculty member in Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra. He is medicinal chemist working in the area of drug design and development against therapeutically validated targets. His current research interest is on developing new chemical entities for the treatment of Tuberculosis (Mycobactin synthetase inhibitors), Viral infections (protease and methyltransferase inhibitors), Cancer (CYP-1A & 1B and Cdk-4 inhibitors) and Depression (MAO inhibitors). Dr. Daniele Castagnolo is Lecturer of Pharmaceutical Chemistry at the Institute of Pharmaceutical Science at King's College London. Dr. Castagnolo's research interests range widely from organic synthetic chemistry to medicinal chemistry and are mainly focused on the design and discovery of bioactive molecules active against Mycobacterium tuberculosis , drug-resistant Gram+/- bacteria and viruses. In addition, Dr. Castagnolo's research group is interested in the development of novel biocatalytic and chemoenzymatic methods for the manufacturing of druglike compounds. Prof. Yusuf Özkay works in the Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eski¿ehir-Turkey. Synthesis and biological evaluation of new enzyme inhibitors, central nervous system related compounds, anticancer, and antimicrobial agents constitute his main research areas. He has more than 50 articles in the journals covered by Science Citation Index, over 100 presentations in the international congresses, and more than 500 citations made to the works of him.

Inhaltsangabe

Key Concepts in Assay Development, Screening and the Properties of Lead and
Development Candidate Compounds. The Application of Fragment-based
Approaches to the Discovery of Drugs for Neglected Tropical Diseases.
Chemical Hybridization Approaches Applied to Natural and Synthetic
Compounds for the Discovery of Drugs Active Against Neglected Tropical
Diseases. Current Inhibitors of Dengue Virus: An Overview. Overview of
Drugs Used Against Zika Virus. Chikungunya Virus Infection: A Review on its
Control and Treatment. Recent Advances in Repositioning Non-Antibiotics
against Tuberculosis and Other Neglected Tropical Diseases. Prospects of
Pre-clinical [6.6.0] Bicyclic Nitrogen Heterocycles in the Treatment of
Tuberculosis. Progress in Antimalarial Drug Discovery and Development. Hits
and Lead Discovery in the Identification of New Drugs against the
Trypanosomatidic Infections. New Chemical Scaffolds to Selectively Target
the Trypanothione Metabolism. The Renewal of Interest in Nitroaromatic
Drugs: Towards New Anti-Kinetoplastid Agents. New Biological Targets for
the Treatment of Leishmaniasis. Curcumin and Neglected Infectious Diseases.
An Overview of Helminthiasis: Current State and Future Directions.