King

Medicinal Chemistry

Principles and Practice
Herausgeber: King, Frank D

• Broschiertes Buch

Produktbeschreibung

"Medicinal Chemistry: Principles and Practices, 2/e" introduces the principles and practices of modern medicinal chemistry, and covers all aspects of drug discovery from the initial lead to final development. It teaches how to convert a lead compound into a potential drug and provides recent case histories as examples of successes. References to specialist monographs and reviews supplement this breadth of coverage, where the reader can find more detail on specific topics of interest if required. For this new edition, the material has been extensively revised to reflect the advances in the methods used in drug discovery over recent years. TOC:An Introduction to Drug Receptor Interactions * Signal Transductionand Second Messengers * Enzyme Inhibitors * The Biological Evaluationof New Compounds * Pharmokinetics * Drug Metabolism * PhysiochemicalProperties and Drug Design * Quantitative Structure-Activity 1= Relationships * Considerations for the Use of Computational Chemistry* Techniques by Medicinal Chemists * "Patent Medicine" * MolcularBiology: A New Route to Drug Discovery * Devising a Research Strategy* Past Approaches to Discovering New Drugs as Medicines *Bioisosteres, Conformational Restriction, and Pro-drugs: Approaches toLead Optimisation * Case History: An Example of a ConformationalRestriction Approach * The Design and Synthesis of Selective ProteinKinase C Inhibitors * Discovery of 1069C - A Novel Synthetic 1= Antihumour Agent with Low Cross-Resistance Potential * The Design andBiological Properties of 'Dipeptoid' Antagonists * Migraine Therapy:From Serotonin to Sumatriptan * Drug Development * Appendices *Subject Index

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Produktdetails

• Verlag: RSC Publishing / Royal Society of Chemistry
• 2nd edition
• Seitenzahl: 472
• Erscheinungstermin: 30. September 2002
• Englisch
• Abmessung: 236mm x 161mm x 25mm
• Gewicht: 762g
• ISBN-13: 9780854046317
• ISBN-10: 0854046313
• Artikelnr.: 22368921

Inhaltsangabe

An Introduction to Drug-Receptor Interactions
Signal Transduction and Second Messengers
Enzyme Inhibitors
The Biological Evaluation of New Compounds
Pharmacokinetics
Drug Metabolism
Physicochemical Properties and Drug Design
Quantitative Structure-Activity Relationships
Considerations for the Use of Computational Chemistry Techniques by Medicinal Chemists
`Patent Medicine'
Molecular Biology - A New Route to Drug Discovery
Devising a Research Strategy
Past Approaches to Discovering New Drugs as Medicines
Bioisosteres, Conformational Restriction, and Pro-drugs: Approaches to Lead Optimisation - Case History: An Example of a Conformational Restriction Approach
The Design and Synthesis of Selective Protein Kinase C Inhibitors
Discovery of 1069C - A Novel Synthetic Antitumour Agent with Low Cross-resistance Potential
The Design and Biological Properties of `Dipeptoid' Antagonists
Migraine Therapy - From Serotonin to Sumatriptan
Drug Development
Appendices
Subject Index.