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Pyrimidine is a class of compound having 6 member ring which is important compound for designing potent bioactive drug. This class of compound has diverse biological activities such as Antibacterial, Anticancer, Antimicrobial, CNS depressant, Anti-convulsant, Anti-inflammatory, Antioxidant, Analgesic, Antihelmentic and herbicidal. The pyrimidine functional group is a present in many biomolecules like DNA and of important drugs like Rosuvastatin, Fluorouracil, Risperidone, Etravirine, Avanafil and Iclaprim.