Membrane Defenses Against Attack by Complement and Perforins

Herausgegeben:Parker, Charles J.

• Broschiertes Buch

Produktbeschreibung

In this volume a comprehensive review of membrane proteinsthat regulate complement and perforin-mediated cytolysis ispresented. A detailed analysisis provided of thebiochemical, molecular, and functional features of theseproteins; the glycosyl phosphatidylinositol linkedproteins are covered, with emphasis placed on the functionalimportance of this type of membrane anchor. Further chaptersinclude reviews of the effects of complement activation oncells that are metabolically active, and of the regulationof cell killing by cytotoxic lymphocytes, considering thesimilarities and disparities between the complement andperforin systems. The therapeutic use of recombinant CR1for immune-mediated pathophysiological processes isdiscussed in a separate section.

Produktdetails

• Current Topics in Microbiology and Immunology 178
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-642-77016-6
• Softcover reprint of the original 1st ed. 1992
• Seitenzahl: 204
• Erscheinungstermin: 16. Dezember 2011
• Englisch
• Abmessung: 235mm x 155mm x 12mm
• Gewicht: 317g
• ISBN-13: 9783642770166
• ISBN-10: 3642770169
• Artikelnr.: 36113300

Inhaltsangabe

List of Contents.- Regulation of Complement by Membrane Proteins: An Overview.- Decay Accelerating Factor (CD55).- Complement Receptor Type 1.- Membrane Cofactor Protein.- Membrane Inhibitor of Reactive Lysis.- Homologous Restriction Factor.- The Effects of Complement Activation on Platelets.- Effects of the Membrane Attack Complex of Complement on Nucleated Cells.- Glycosyl-Phosphatidylinositol Anchoring of Membrane Proteins.- Paroxysmal Nocturnal Hemoglobinuria.- Perforin-Structure, Function, and Regulation.