In recent years, scientific interest has been growing in the study of reproductive disorders in patients with diabetes mellitus, which is associated with advances in the treatment of the disease, which significantly increase the life expectancy of patients with diabetes mellitus. to delay the development of serious complications of the disease as much as possible. This protein hormone regulates the synthesis of glycogen in the liver, the use of glucose by insulin-dependent tissues (adipose tissue, muscles), the passage of amino acids through the cytoplasmic membrane and protein synthesis, the attachment of fatty acids to triglycerides and fats. The monograph explains the differential approach to the treatment of menopausal syndrome in patients with type 2 diabetes mellitus.