Faizal Asumda

Mesenchymal Stem Cell Aging: Implications for Cellular Cardiomyoplasty

A Theoretical Exposition

• Broschiertes Buch

Produktbeschreibung

Cell-based therapy geared at the replacement of lost myocardial cells, and subsequent regeneration of damaged myocardial tissue is a viable and attractive therapeutic option. Bone Marrow derived Mesenchymal stem cells (BM-MSCs) have emerged in recent years as a practical and clinically relevant stem cell for the technique of cellular cardiomyoplasty. Enthusiasm for BM-MSCs is however tempered by evidence that cells from older donors show measurable and qualitative changes in their efficacy. This work provides a theoretical exposition on why BM-MSCs are a preferred cell source for cardiac regeneration, outlines aspects of their appeal that is diminished by natural aging, and discusses approaches to their in vitro cardiomyogenic differentiation. Also presented is a theoretical discussion of the physiological significance of nuclear cardiac troponins and tropomyosin with regard to BM-MSC specific cardiomyogenesis, the importance of the stem cell niche environment, and its potential contribution to diminished BM-MSC plasticity with advancing age.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Aufl.
• Seitenzahl: 72
• Englisch
• Abmessung: 220mm
• ISBN-13: 9783659186714
• ISBN-10: 3659186716
• Artikelnr.: 36158703

Autorenporträt

Faizal completed his undergraduate and graduate studies at Bucknell University and Florida State University, respectively. As a graduate student, his primary research focus was on the understanding of adult stem cell aging and cardiomyogenesis, and their application to cardiovascular disease.