Human metabolism and climate change can modulate immunity and contribute to the genesis of autoimmune disease. Actinidic archaea has been related to global warming and human diseases especially autoimmune diseases like systemic lupus erythematosis, multiple sclerosis and rheumatoid arthritis. The growth of endosymbiotic actinidic archaea in relation to climate change and global warming leads to neanderthalisation of the human mind-body system. Neanderthal anthropometry and metabolonomics has been described in autoimmune diseases like systemic lupus erythematosis, multiple sclerosis and rheumatoid arthritis especially the Warburg phenotype and hyperdigoxinemia. Digoxin produced by archaeal cholesterol catabolism produces neanderthalisation. Prefrontal cortical atrophy and cerebellar hyperplasia has been related to autoimmune diseases like systemic lupus erythematosis, multiple sclerosis and rheumatoid arthritis. This leads on to dysautonomia with sympathetic hyperactivity and parasympathetic neuropathy in these disorders. Actinidic archaeal related cerebellar dominance leads to changes in brain function.
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