Human metabolism and climate change can modulate brain metabolism and genesis of neuropsychiatric disorders. Actinidic archaea has been related to global warming and human diseases especially schizophrenia, autism and epilepsy. The growth of endosymbiotic actinidic archaea in relation to climate change and global warming leads to neanderthalisation of the human mind-body system. Neanderthal anthropometry and metabolonomics has been described in schizophrenia, autism and epilepsy especially the Warburg phenotype and hyperdigoxinemia. Digoxin produced by archaeal cholesterol catabolism produces neanderthalisation. Prefrontal cortical atrophy and cerebellar hyperplasia has been related to schizophrenia, autism and epilepsy in this communication. This leads on to dysautonomia with sympathetic hyperactivity and parasympathetic neuropathy in these disorders. Actinidic archaeal related cerebellar dominance leads to changes in brain function.
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