The book is intended for a wide range of readers - endocrinologists, cardiologists, neurologists, gynecologists, psychiatrists, psychologists, dieticians, general practitioners, medical students, specializing doctors and patients with obesity, metabolic syndrome, type 2 diabetes mellitus. The monography contains data of the author s research on neurotrophines, mast cells, chronic inflammatory and psychoemotional distress, changes in salivary glands and thyroidea, chormonal disbalance in metabolic syndrome. By revealing little-known scientific facts about NGF and etiopathogenetic mechanisms of development of cardio-metabolic disease, this book provides an answer to the ways of successful treatment of the abovementioned socially significant diseases.