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Both the animals and humans with generalized lipodystrophy develop signs of metabolic syndrome in the absence of adipose tissue; and the metabolic syndrome progresses to type 2-diabetes. Metabolic syndrome (Mets) is a disease multiple factors that commonly appear together. MetS is defined by a cluster of interconnected factors that directly elevate the dangerous of coronary heart disease, other forms of cardiovascular atherosclerotic diseases, and diabetes mellitus type 2. Treatment usually involves the expensive. We believed the rates of Mets reduce by lifestyle changes and health nutrition. Nutrition and foods are related with Mets. On basis studies, health nutrition can decrease Mets. The most of people of world are turning to the use of dietary vegetables, medicinal herbs, PUFA, omega 3 and etc to prevent or treat Mets. This book brings together experts working on the different aspects of nutrient supplementation, foods, and plant extracts in prevent or treat Mets. Book chapters include introduction, treatment, energy, diet, lipids, proteins, carbohydrates, proteins, vitamins, minerals and herbal. Moreover, it is also presented various ways for treatment of metabolic syndrome.