This is the first volume on the role of metal ions in regulating genes to focus not only on toxicity effects of metals but also on the role of metal ions in normal metabolisms, in both prokaryotes and in eukaryotes. This book is a comprehensive treatment of the role of metal ions in gene regulation, and it will be of great utility for those doing basic biological and biomedical research.
This is the first volume on the role of metal ions in regulating genes to focus not only on toxicity effects of metals but also on the role of metal ions in normal metabolisms, in both prokaryotes and in eukaryotes. This book is a comprehensive treatment of the role of metal ions in gene regulation, and it will be of great utility for those doing basic biological and biomedical research.
1. Overview of Cellular Inorganic Metabolism and the Need for Gene Regulation.- I: Bacterial Metal Metabolism.- 2. Control of Bacterial Iron Transport by Regulatory Proteins.- 3. Metal Cation Regulation in Gram-Positive Bacteria.- 4. Two-Component Systems in the Regulation of Heavy Metal Resistance.- 5. Phosphate Signaling and the Control of Gene Expression in Escherichia coli.- II: Animal Metal Metabolism.- 6. Translational Regulation of Bioiron.- 7. The Iron Responsive Element (IRE), the Iron Regulatory Protein (IRP), and Cytosolic Aconitase: Posttranscriptional Regulation of Mammalian Iron Metabolism.- 8. Mechanisms for Induction and Rerepression of Ferritin Synthesis.- 9. Metallothionein Gene Regulation in Mouse Cells.- 10. Menkes' and Wilson's Diseases: Genetic Disorders of Copper Transport.- III: Lower Eukaryotes and Plants.- 11. Metal Ion Stress in Yeast.- 12. Yeast Metallothionein Gene Regulation.- 13. The Molecular Biology of Iron and Zinc Uptake in Saccharomyces cerevisiae.- 14. Metallothionein Gene Regulation in Cyanobacteria.- 15. Metallothionein-like Genes and Phytochelatins in Higher Plants.- 16. Regulation of Ferritin Synthesis and Degradation in Plants.- 17. Reciprocal, Copper-Responsive Accumulation of Plastocyanin and Cytochrome c6 in Algae and Cyanobacteria: A Model for Metalloregulation of Metalloprotein Synthesis.
1. Overview of Cellular Inorganic Metabolism and the Need for Gene Regulation.- I: Bacterial Metal Metabolism.- 2. Control of Bacterial Iron Transport by Regulatory Proteins.- 3. Metal Cation Regulation in Gram-Positive Bacteria.- 4. Two-Component Systems in the Regulation of Heavy Metal Resistance.- 5. Phosphate Signaling and the Control of Gene Expression in Escherichia coli.- II: Animal Metal Metabolism.- 6. Translational Regulation of Bioiron.- 7. The Iron Responsive Element (IRE), the Iron Regulatory Protein (IRP), and Cytosolic Aconitase: Posttranscriptional Regulation of Mammalian Iron Metabolism.- 8. Mechanisms for Induction and Rerepression of Ferritin Synthesis.- 9. Metallothionein Gene Regulation in Mouse Cells.- 10. Menkes' and Wilson's Diseases: Genetic Disorders of Copper Transport.- III: Lower Eukaryotes and Plants.- 11. Metal Ion Stress in Yeast.- 12. Yeast Metallothionein Gene Regulation.- 13. The Molecular Biology of Iron and Zinc Uptake in Saccharomyces cerevisiae.- 14. Metallothionein Gene Regulation in Cyanobacteria.- 15. Metallothionein-like Genes and Phytochelatins in Higher Plants.- 16. Regulation of Ferritin Synthesis and Degradation in Plants.- 17. Reciprocal, Copper-Responsive Accumulation of Plastocyanin and Cytochrome c6 in Algae and Cyanobacteria: A Model for Metalloregulation of Metalloprotein Synthesis.
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