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Metal Nanoparticles for Cancer Therapy provides an update on the current state-of-the-art trends in multifunctional metal nanoparticles for cancer therapy. The contributions received in this collection further strengthen the metal-based nanoparticles for multimodel imaging-guided cancer therapy, illustrating the various methods possible and unveiling what the future may bring. This Special Issue aims to share recent progress and trends in this field. It is an essential resource for researchers, academics, and professionals interested in the potential of metal nanoparticles for cancer therapy.