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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Methadone maintenance is the use of methadone over a prolonged time as treatment for someone who is addicted to opioids (such as heroin) or has severe pain problems that are resistant to other drugs. Methadone maintenance has been used to treat opioid dependence for more than 45 years. Therapeutic dosing is contingent upon individual patient needs, and the therapeutic dosage range is generally between 25 150 mg.