Method Development and Validation for Voriconazole Estimation - Srinivasa Rao, Yarguntla;Vara Prasada Rao, K.
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A rapid, sensitive, and specific RP-HPLC method with UV detection was developed and validated for the determination of voriconazole. Chromatography was performed on an Enable C18 G column (250 × 4.6 mm) in isocratic mode, using a mobile phase of methanol and acetonitrile (60:40, v/v). The flow rate was set at 1 mL/min, and the effluent was monitored at 223 nm. Chromatographic analysis revealed a main peak for voriconazole at a retention time of 2.841 minutes. Methanol was selected as the solvent for the analysis, with the max determined to be 223 nm. The method exhibited linearity over a…mehr

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Produktbeschreibung
A rapid, sensitive, and specific RP-HPLC method with UV detection was developed and validated for the determination of voriconazole. Chromatography was performed on an Enable C18 G column (250 × 4.6 mm) in isocratic mode, using a mobile phase of methanol and acetonitrile (60:40, v/v). The flow rate was set at 1 mL/min, and the effluent was monitored at 223 nm. Chromatographic analysis revealed a main peak for voriconazole at a retention time of 2.841 minutes. Methanol was selected as the solvent for the analysis, with the max determined to be 223 nm. The method exhibited linearity over a concentration range of 5-30 µg/mL. Validation parameters, including linearity, range, precision, accuracy, limit of detection (LOD), and limit of quantitation (LOQ), were assessed and met the required standards.
Autorenporträt
The author earned his B.Pharmacy, M.Pharm, and Ph.D. from Andhra University. His postdoctoral research at Kyoto Pharmaceutical University, Japan, focused on designing and evaluating microneedle drug delivery systems for controlled release. He received the "Young Scientist Award-2016" from CEGR, New Delhi, and won four Best Research Paper Awards.