Methylated Genes and Glioma Treatment" is a book written by J.JAYALAKSHMI that delves into the complex relationship between hypermethylated connexin genes and aggressive glioma, a type of brain cancer. The book discusses how altered metabolism and hypoxia play a pivotal role in the development and progression of this disease, with hypermethylation of connexin genes being a key factor that contributes to chemoresistance in glioma. The book explores the latest research on hypermethylated connexin genes and their role in glioma, including the epigenetic mechanisms that underlie this process. It also discusses the potential of naringenin, a flavonoid found in citrus fruits, as an agent that can help overcome chemoresistance in glioma. Throughout the book, J.JAYALAKSHMI provides a detailed analysis of the challenges facing the development of effective treatments for glioma, as well as the potential of new approaches that target the underlying molecular mechanisms of the disease. The book also discusses the potential for personalized medicine in the treatment of glioma, where treatments can be tailored to individual patients based on their unique genetic makeup.