Irfan Pervaiz, Saeed Ahmad

Microbial Biotransformation of Ezetimibe

Investigations on metabolism of Fluorinated Drugs

• Broschiertes Buch

Produktbeschreibung

The phenomenon of microbial biotransformation has gained significance regarding imitation of mammalian metabolism of drugs as well as rendering chemical diversity in these compounds via functionalization of unreactive centres enabling further modification of biologically active molecules. This can be attributed mainly to the diverse enzymatic machinery naturally present in microorganisms that transcends limited probability of structural diversity generated via conventional synthetic routes. It is more efficient/cost effective than using microsomal preparations from hepatocytes and raises no ethical issues such as those encountered with the dosing of animals. Another pertinent aspect of microbial biotransformation is bioremediation of hazardous chemicals in environment. Since fluorine atom is present in majority of pharmacological agents contamination of the environment by such compounds is worthy of separate study. This book describes microbial biotransformation of ezetimibe by two different fungi. Fungal enzymes acted on -OH group of propyl carbon as well as lactam ring. This book is useful for research students working in area of drug metabolism/development.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 88
• Erscheinungstermin: 10. September 2016
• Englisch
• Abmessung: 220mm x 150mm x 6mm
• Gewicht: 149g
• ISBN-13: 9783659904240
• ISBN-10: 3659904244
• Artikelnr.: 45735777

Autorenporträt

Irfan Pervaiz is a PhD Scholar in Pharmaceutical Chemistry at Faculty of Pharmacy & Alternative Medicine, Islamia University of Bahawalpur, Pakistan. His research interests include isolation, structure elucidation of natural products, biosynthesis of secondary metabolites, biocatalysis, drug metabolism.