Microbial Functional Genomics offers a timely summary of the principles, approaches, and applications. It presents a comprehensive review of microbial functional genomics, covering microbial diversity, microbial genome sequencing, genomic technologies, genome-wide functional analysis, applied functional genomics, and future directions. An introduction will offer a definition of the field and an overview of the historical and comparative genomics aspects.
Microbial Functional Genomics offers a timely summary of the principles, approaches, and applications. It presents a comprehensive review of microbial functional genomics, covering microbial diversity, microbial genome sequencing, genomic technologies, genome-wide functional analysis, applied functional genomics, and future directions. An introduction will offer a definition of the field and an overview of the historical and comparative genomics aspects.
Jizhong Zhou is a Staff Scientist and science leader for the Microbial Genomics and Ecology section in the Environmental Sciences Division of Oak Ridge National Laboratory. He is the author of more than 50 publications on molecular biology, microbial genomics, molecular evolution, microbial ecology, bioremediation, and theoretical ecology. Ying Xu is the group leader of the computational protein structure group of Life Sciences Division of Oak Ridge National Laboratory. He serves on a number of scientific review committees including the NIH review panel on structural genomics. James M. Tiedje is University Distinguished Professor of Microbial Ecology and Director of the National Science Foundation Center for Microbial Ecology at Michigan State University. He is a Fellow of ASA, SSSA, AAAS, the International Institute of Biotechnology and a Fellow of the American Academy of Microbiology. Dorothea Thompson is currently a Research Staff Scientist in the Environmental Sciences Division at Oak Ridge National Laborat ory (ORNL), working in the area of microbial functional genomics. She received her Ph.D. in molecular microbiology from The Ohio State University (Columbus, OH) and master's degrees from Virginia Tech and the Pennsylvania State University. Dr. Thompson pursued postdoctoral training in bacterial pathogen typing and vaccine development at the U. S. Food and Drug Administration in Bethesda, Maryland, and in DNA microarray-based gene expression analysis at ORNL before becoming a staff member in 2002. Her research interests and expertise focus on the mechanisms of transcription regulation in prokaryotic systems and the use of genomic technologies, specifically DNA microarrays, to describe the molecular basis underlying cellular adaptation to environmental stresses.
Inhaltsangabe
Foreword. Preface. Acknowledgments. 1. Genomics: Toward a Genome-level Understanding of the Structure, Functions, and Evolution of Biological Systems (Jizhong Zhou, Dorothea K. Thompson, and James M. Tiedje). 2. Microbial Diversity and Genomics (Konstantinos Konstantinidis and James M. Tiedje). 3. Computational Genome Annotation (Ying Xu). 4. Microbial Evolution from a Genomics Perspective (Jizhong Zhou and Dorothea K. Thompson). 5. Computational Methods for Functional Prediction of Genes (Ying Xu). 6. DNA Microarray Technology (Jizhong Zhou and Dorothea K. Thompson). 7. Microarray Gene Expression Data Analysis (Ying Xu). 8. Mutagenesis as a Genomic Tool for Studying Gene Function (Alexander S. Beliaev). 9. Mass Spectrometry (Nathan VerBerkmoes, Joshua Sharp, and Robert Hettich). 10. Identification of Protein-Ligand Interactions (Timothy Palzkill). 11. The Functional Genomics of Model Organisms: Addressing Old Questions from a New Perspective (Dorothea K. Thompson and Jizhong Zhou). 12. Functional Genomic Analysis of Bacterial Pathogens and Environmentally Significant Microorganisms (Dorothea K. Thompson and Jizhong Zhou). 13. The Impact of Genomics on Antimicrobial Drug Discovery and Toxicology (Dorothea K. Thompson and Jizhong Zhou). 14. Application of Microarray-based Genomic Technology to Mutation Analysis and Microbial Detection (Jizhong Zhou and Dorothea K. Thompson). 15. Future Perspectives: Genomics Beyond Single Cells (James M. Tiedje and Jizhong Zhou). Glossary. References. Index.
Foreword. Preface. Acknowledgments. 1. Genomics: Toward a Genome-level Understanding of the Structure, Functions, and Evolution of Biological Systems (Jizhong Zhou, Dorothea K. Thompson, and James M. Tiedje). 2. Microbial Diversity and Genomics (Konstantinos Konstantinidis and James M. Tiedje). 3. Computational Genome Annotation (Ying Xu). 4. Microbial Evolution from a Genomics Perspective (Jizhong Zhou and Dorothea K. Thompson). 5. Computational Methods for Functional Prediction of Genes (Ying Xu). 6. DNA Microarray Technology (Jizhong Zhou and Dorothea K. Thompson). 7. Microarray Gene Expression Data Analysis (Ying Xu). 8. Mutagenesis as a Genomic Tool for Studying Gene Function (Alexander S. Beliaev). 9. Mass Spectrometry (Nathan VerBerkmoes, Joshua Sharp, and Robert Hettich). 10. Identification of Protein-Ligand Interactions (Timothy Palzkill). 11. The Functional Genomics of Model Organisms: Addressing Old Questions from a New Perspective (Dorothea K. Thompson and Jizhong Zhou). 12. Functional Genomic Analysis of Bacterial Pathogens and Environmentally Significant Microorganisms (Dorothea K. Thompson and Jizhong Zhou). 13. The Impact of Genomics on Antimicrobial Drug Discovery and Toxicology (Dorothea K. Thompson and Jizhong Zhou). 14. Application of Microarray-based Genomic Technology to Mutation Analysis and Microbial Detection (Jizhong Zhou and Dorothea K. Thompson). 15. Future Perspectives: Genomics Beyond Single Cells (James M. Tiedje and Jizhong Zhou). Glossary. References. Index.
Rezensionen
"...The approach throughout is thoughtful and blessedly hype-free." ( Genetical Research , Vol.84, 2004)
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