The book reports research results from different disciplines.Topics include isolation and structure determination of new antibiotics and other biologically active secondary metabolites, biosynthesis of antibiotics in particular lantibiotics, nikkomycins and glycosyl antibiotics, mode of action of bacterial protein toxins, import and export of proteins, active transport and regulation of iron, the enzymology of murein biogenesis and morphogenesis, mode of action and biosynthesis of hopanoids, and second messenger systems of Paramecium. The book gives answers to questions: how to use the…mehr
The book reports research results from different disciplines.Topics include isolation and structure determination of new antibiotics and other biologically active secondary metabolites, biosynthesis of antibiotics in particular lantibiotics, nikkomycins and glycosyl antibiotics, mode of action of bacterial protein toxins, import and export of proteins, active transport and regulation of iron, the enzymology of murein biogenesis and morphogenesis, mode of action and biosynthesis of hopanoids, and second messenger systems of Paramecium.
The book gives answers to questions: how to use the biosynthetic abilities of micro-organisms to produce new biologically active compounds, how to synthesize (microbiologically or chemically) new structures, and how to test their biological activities.
Preface Introduction Antibiotics and Other Biologically Active Microbial Metabolites Screening for New Secondary Metabolites From Microorganisms Biosynthesis of the Lantibiotics Epidermin and Gallidermin Fermentation of the Lantibiotics Epidermin and Gallidermin Genetics of Nikkomycin Production in Steptomyces tendae Tü901 Glycosylated Antibiotics: Studies on Genes Involved in Deoxysugar Formation, Modification and Attachment, and Their Use in Combinatorial Biosynthesis Analysis of the Biosynthesis of Glycopeptide Antibiotics: Basis for Creating new Structures by Combinatorial Biosynthesis Homologous Recombination and the Induction of the SOS Response in Antibiotic-producing Streptomycetes Membrane Processes Regulated Transport and Signal Transfer Channels Involved in Bacterial Iron Supply Iron Transport in Gram-negative and Gram-positive Bacteria Regulation of the Ferric-Citrate Transport System by a Novel Transmembrane Transcription Control Structure, Function, Import, and Immunity of Colcins Structure, Activity, Activation, and Secrection of the Serratia marcescens Hemolysin/Cytotoxin Staphylococcal Lipases: Molecular Characterization and Use as an Expression and Secretion System A Multienzyme Complex Involved in Murein Synthesis of Escherichia coli The Changing Path of Hopanoid Research: From Condensing Lipids to new Membrane Enzymes Genetic and Biochemical Analysis of the Biosynthesis of the Carotenoid Staphyloxanthin of Staphylococcus aureus Second Messenger System in Paramecium Chemical Synthesis and Structure Elucidation Structure Elucidation and Chemical Synthesis of Microbial Metabolites Documentation Documentation of the collaborative research centre 323 List of institutes involved List of supported project areas Alphabetical list of members and participants Support of young scientists Alphabetical list of guests International cooperation International conferences Funding
Preface Introduction Antibiotics and Other Biologically Active Microbial Metabolites Screening for New Secondary Metabolites From Microorganisms Biosynthesis of the Lantibiotics Epidermin and Gallidermin Fermentation of the Lantibiotics Epidermin and Gallidermin Genetics of Nikkomycin Production in Steptomyces tendae Tü901 Glycosylated Antibiotics: Studies on Genes Involved in Deoxysugar Formation, Modification and Attachment, and Their Use in Combinatorial Biosynthesis Analysis of the Biosynthesis of Glycopeptide Antibiotics: Basis for Creating new Structures by Combinatorial Biosynthesis Homologous Recombination and the Induction of the SOS Response in Antibiotic-producing Streptomycetes Membrane Processes Regulated Transport and Signal Transfer Channels Involved in Bacterial Iron Supply Iron Transport in Gram-negative and Gram-positive Bacteria Regulation of the Ferric-Citrate Transport System by a Novel Transmembrane Transcription Control Structure, Function, Import, and Immunity of Colcins Structure, Activity, Activation, and Secrection of the Serratia marcescens Hemolysin/Cytotoxin Staphylococcal Lipases: Molecular Characterization and Use as an Expression and Secretion System A Multienzyme Complex Involved in Murein Synthesis of Escherichia coli The Changing Path of Hopanoid Research: From Condensing Lipids to new Membrane Enzymes Genetic and Biochemical Analysis of the Biosynthesis of the Carotenoid Staphyloxanthin of Staphylococcus aureus Second Messenger System in Paramecium Chemical Synthesis and Structure Elucidation Structure Elucidation and Chemical Synthesis of Microbial Metabolites Documentation Documentation of the collaborative research centre 323 List of institutes involved List of supported project areas Alphabetical list of members and participants Support of young scientists Alphabetical list of guests International cooperation International conferences Funding
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