Ashraf Farag Elbaz, Yaser Hagag Mohamed

Microbial Production of Some Products of Cucurbitacin E Glucoside

Herausgegeben:Hussein, Mohamed Addalla

• Broschiertes Buch

Produktbeschreibung

The book aimed to reveal degradation of Cucurbitacin E glucoside obtained from Citrullus colocynthis (L.) (Hanzal) into Cucurbitacin E and glucose by mean of microbial biotransformation using Curvularia lunata NRRL 2178 as a source of beta-glucosidase. All the instrumental data obtained by highly advanced techniques, confirmed the microbial conversion of cucurbitacin E glucoside into cucurbitacin E and glucose indicating effect of enzyme in the hydrolysis process by splitting of glucose from the anomeric carbon atom. The effect of the cucurbitacin E glucoside and cucurbitacin E on the proliferation of Hep-G2 cells was studied. The treatment of Hep-G2 cells with cucurbitacin E led to a high inhibition of the cell proliferation, which revealed a moderate anti-tumor activity of the cucurbitacin E against hepatic carcinoma, while cucurbitacin E glucoside had no cytotoxic effect on Hep-G2 cells. The study showed the effect of the compounds on the proliferation of HCT-116 cells; the two compounds were not cytotoxic as indicated by their IC50 values. On the other hand, the treatment of T-lymphocyte cells with cucurbitacin E resulted in increase in the cell proliferation.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 140
• Erscheinungstermin: 7. April 2014
• Englisch
• Abmessung: 220mm x 150mm x 9mm
• Gewicht: 227g
• ISBN-13: 9783659293481
• ISBN-10: 3659293482
• Artikelnr.: 40828815

Autorenporträt

Prof.Dr. Mohamed Abdalla Hussein,Professor of Biochemistry,Faculty of Pharmacy,October 6th University, Egypt. Prof.Dr. Ashraf Farag Elbaz,Head of the Industrial Biotechnology Department, Genetic Engineering and Bitechnology Institute, Egypt. Dr. Yaser Hagag Mohamed, Researcher Chemist, Central lab., Greater Cairo Drinking Water Company, Egypt.