This book aims to provide a comprehensive exploration of microchannel heat exchangers (MCHX), focusing on their design principles, diverse applications, and recent advances in the field. As an essential component in various industries, microchannel heat exchangers have gained significant attention due to their unique characteristics, such as high surface area-to-volume ratio, compact size, and enhanced heat transfer capabilities. This book aims to serve as a valuable resource for researchers, engineers, and practitioners involved in thermal management, HVAC, refrigeration, and related fields. The comprehensive coverage of design principles, applications, and recent advancements will contribute to a deeper understanding of the potential and challenges associated with microchannel heat exchangers.