Microorganisms as platform for production of bioactive compounds - Buzzola, Gloria
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Phenylpropanoids and derived flavonoids are natural plant products presenting many positive effects on human health. Besides that, they are important compounds regarding several plant physiological aspects. The biosynthetic pathway is composed of several enzymatic steps and is object of many on-going studies on metabolic engineering. In this context, the heterologous expression in microbes and combinatorial biosynthesis are interesting tools to increase production yields of these plant secondary metabolites. In this project the main goal was to establish a production platform for phloridzin, a…mehr

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Produktbeschreibung
Phenylpropanoids and derived flavonoids are natural plant products presenting many positive effects on human health. Besides that, they are important compounds regarding several plant physiological aspects. The biosynthetic pathway is composed of several enzymatic steps and is object of many on-going studies on metabolic engineering. In this context, the heterologous expression in microbes and combinatorial biosynthesis are interesting tools to increase production yields of these plant secondary metabolites. In this project the main goal was to establish a production platform for phloridzin, a bioactive compound found in apple trees, by reconstruction of phenylpropanoid/chalcone pathway as a modular system in a single E. coli cell.
Autorenporträt
Gloria Buzzola was born in 1988 in Trento, Italy. Gloria graduated in Industrial Biotechnology in 2013 and during her studies, she made an internship program at the Natural Products Biotechnology Research Group - Fondazione Edmund Mach, where she worked on the project and she keened about the molecular biology.