The monograph is presented in eight chapters. A brief Introduction to microprocessor development is presented in the first chapter. The 8086/8088 microprocessor, its register model, instruction classification and the addressing modes are discussed in the second chapter. The third chapter deals with the assembly language programming including the interrupts of the processor. Hard ware of the 8086 processor including the word organized memory banks are discussed in the fourth chapter. 8255 PPI, its control word formats, interfacing D/A and A/D converters to 8086 are discussed in the fifth chapter. Interfacing key boards, 7-segment displays and other devices are discussed in the sixth chapter. The seventh chapter describes the 8051 microcontroller, its hard ware features, addressing modes and programming. Compact and cost effective biomedical systems realized by my students are presented in the eighth chapter.